贝类细胞自噬与凋亡的研究进展OA
Research Progress on Autophagy and Apoptosis of Shellfish Cells
自噬和凋亡是细胞命运调控的两种基本病理生理机制.现有通过对哺乳动物进行研究发现,参与反应的信号通路通过各种串扰机制相互连接.然而,关于双壳贝类等无脊椎动物中的自噬和凋亡串扰的研究仍相对较少.基于此,文章主要介绍细胞自噬和凋亡的分子机制及两者之间的联系,并对双壳贝类的自噬和凋亡的研究进展进行论述,从而探讨自噬与凋亡在水生生物发育和进化过程中的关键作用,以期为进一步探索无脊椎动物自噬与凋亡的分子机制奠定理论基础.
Autophagy and apoptosis are two fundamental pathophysiological mechanisms of cell fate regulation.According to the studies of mammals,it has been found that signaling pathways involved in the response are significantly interconnected through various crosstalk mechanisms.However,autophagy and apoptosis crosstalk have been little studied in invertebrates such as bivalves.In this paper,it focuses on the molecular mechanisms of cellular autophagy and apoptosis and their connections,and discusse the research progress of autophagy and apoptosis of bivalve shellfish,to explore the key roles of autophagy and apoptosis in aquatic organisms'development and evolution,and provide theoretical foundations for further exploration of the molecular mechanisms of autophagy and apoptosis in invertebrates.
王燕锐;徐慧;黄那那;杨喆;吴杰连
江西科技师范大学,江西南昌 330013
自噬凋亡贝类
autophagyapoptosisshellfish
《工业微生物》 2024 (003)
39-42 / 4
江西省科技厅基金资助项目(20202BABL203041);江西省教育厅自然科学基金资助项目(GJJ211120);江西省药物设计与评价重点实验室开放项目(JKLDE-KF-2202).
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