工业微生物2024，Vol.54Issue(3)：58-60,3.DOI:10.3969/j.issn.1001-6678.2024.03.019
银杏叶提取物对阿尔茨海默病小鼠模型的治疗潜力及其可能的作用机制
The Therapeutic Potential and Possible Mechanisms of Action of Ginkgo Biloba Extract on the Alzheimer's Disease Mouse Model
摘要
Abstract
This study discusses the effect of the Ginkgo biloba extract EGb 761 on the Aβdeposition of Alzheimer's disease(AD)mouse model,and establish the AD mouse model through the intraventricular administration and intervened by orally administering EGb 761.The study employs the behavioral test(Y-maze test)to evaluate the impact of EGb 761 on the cognitive function of AD mice;meanwhile,tests the Aβ1-42 and pT181-tau protein level by using ELISA to explore the influence of EGb 761 on the expression of hallmark proteins of AD.The results remind us that EGb 761 can significantly mitigate the Aβ deposition and tau protein phosphorylation in an AD mouse model,which reveals that EGb 761 may exert its anti-AD effect by modulating the pathway of Aβgeneration and the process of tau protein phosphorylation.关键词
阿尔茨海默病/银杏叶提取物/淀粉样蛋白/tau蛋白/神经保护Key words
Alzheimer's disease/Ginkgo biloba extract/Amyloid-beta/Tau protein/Neuroprotection引用本文复制引用
王浩玉,荆治华..银杏叶提取物对阿尔茨海默病小鼠模型的治疗潜力及其可能的作用机制[J].工业微生物,2024,54(3):58-60,3.基金项目
山西医科大学汾阳学院校级课题项目"银杏叶提取物对2型糖尿病伴阿尔茨海默病样大鼠Tau蛋白磷酸化途径的影响及其机制的探讨"(编号:2017D05). （编号:2017D05）
