广州化学2024，Vol.49Issue(3)：52-56,5.DOI:10.16560/j.cnki.gzhx.20240319
粘度响应近红外荧光探针及成像应用
Viscosity Responsive Near Infrared Fluorescence Probe and Its Imaging Application
摘要
Abstract
Probe L was synthesized using ethyl 3-dehydroshikimate as the raw material through an aromatic condensation reaction.The structure of probe L was confirmed using magnetic resonance imaging,infrared spectroscopy and high-resolution mass spectrometry.Probe L exhibited significant fluorescence enhancement in high-viscosity solvents such as glycerol and extremely weak fluorescence in low-viscosity solvents,confirming its notable viscosity response feature.Moreover,probe L demonstrated good anti-interference capability,high pH stability and good photo-stability.Leveraging the viscosity-fluorescence response of probe L,fluorescence imaging of viscosity changes in HeLa cells induced by LPS or Nystatin was conducted.关键词
荧光探针/莽草酸/粘度探针/成像应用/近红外发射Key words
fluorescence probe/shikimic acid/viscosity probe/imaging applications/near infrared emission分类
化学化工引用本文复制引用
林森,鞠萍,张恩生..粘度响应近红外荧光探针及成像应用[J].广州化学,2024,49(3):52-56,5.基金项目
山东省高等学校科技创新团队项目(2021KJ070) （2021KJ070）
山东省自然科学基金(ZR2023QB047) （ZR2023QB047）
