化工进展2024，Vol.43Issue(6)：3277-3284,8.DOI:10.16085/j.issn.1000-6613.2023-0853
基于温度和葡萄糖双重响应性共聚物微囊的胰岛素控释载体
Insulin controlled release carriers based on temperature and glucose dual-response copolymer microcapsules
摘要
Abstract
The treatment of diabetes is to seek the carriers that can monitor the blood glucose level immediately and release the required dosage of insulin accurately.Therefore,the development of intelligent insulin controlled release carriers that can self-regulate according to the change of glucose concentration has important clinical application values.This work creates a feasible strategy for the preparation of temperature and glucose dual-response copolymer microcapsules that can be used for insulin controlled release.Firstly,random copolymers with N-isopropylacrylamide(NIPAAm)and 3-acrylamidophenylboronic acid(AAPBA)as the main components were synthesized by free radical polymerization.The surfaces of glass microspheres were covered with copolymer solution by bottom-spray coating technology.Then the copolymers were grafted on the surfaces of the microspheres by heating and annealing,and the templates were dissolved by hydrofluoric acid to form the copolymer microcapsules.The chemical composition,size distribution,equilibrium swelling,surface morphology,stability,cytotoxicity and controlled release capacity of insulin were investigated and analyzed.The results showed that the copolymer microcapsules had relatively uniform size distribution,good stability,no cytotoxicity,significant temperature and glucose sensitivity,and could be applied for loading of insulinoma cells,as well as controlled release of secreted insulin.The scheme for preparing the smart responsive insulin controlled release carriers has access to a powerful tool for creating artificial pancreas.关键词
复合材料/聚合物/凝胶/载体/多孔介质/温度敏感性/葡萄糖敏感性Key words
composites/polymers/gels/support/porous media/temperature sensitivity/glucose sensitivity分类
化学化工引用本文复制引用
杨磊,邱广薇,李思言,葛宏程,孙园园,王菲,范晓光..基于温度和葡萄糖双重响应性共聚物微囊的胰岛素控释载体[J].化工进展,2024,43(6):3277-3284,8.基金项目
国家自然科学基金(21604034) （21604034）
辽宁省教育厅科学研究一般项目(JYTMS20231427,L2020015). （JYTMS20231427,L2020015）
