肠道菌群代谢产物氧化三甲胺通过抑制Keap1/Nrf2信号通路激活发挥促动脉粥样硬化作用OACSTPCD
Gut Microbiota Metabolite Trimethylamine N-oxide Promotes Atherosclerosis by Inhibiting the Keap1/Nrf2 Signaling Pathway
目的:研究肠道菌群(GM)代谢产物氧化三甲胺(TMAO)对动脉粥样硬化(AS)的影响及其相关机制.方法:按照随机数字表法将雄性小鼠分为对照组、模型组、TMAO 组、Keap1/Nrf2 激动剂RTA-408 组和TMAO+RTA-408 组,每组12 只.其中,模型组小鼠采用高脂饲料喂养,TMAO组小鼠在高脂饲料中加1%胆碱,造模周期为12 周.造模结束后,RTA-408 组和TMAO+RTA-408 组小鼠每天腹腔单次注射RTA-408(100…查看全部>>
Objective:To investigate the effects of the gut microbiota(GM)metabolite trimethylamine N-oxide(TMAO)on atherosclerosis(AS)and its related mechanisms.Methods:Male mice were randomly di-vided into the control group,model group,TMAO group,Keap1/Nrf2 activator RTA-408 group,and TMAO+RTA-408 group,with 12 mice in each group.The model group mice were fed a high-fat diet,while the TMAO group mice were fed a high-fat diet with 1%choline for a modeling period of 12 …查看全部>>
单思阳;郭凡;杨浩;马洁;张裕祥
新疆医科大学第六附属医院,新疆 乌鲁木齐 830092新疆医科大学第三附属医院检验科,新疆 乌鲁木齐 830054新疆医科大学第六附属医院,新疆 乌鲁木齐 830092新疆医科大学第六附属医院,新疆 乌鲁木齐 830092新疆医科大学第六附属医院,新疆 乌鲁木齐 830092
动脉粥样硬化肠道菌群代谢产物氧化三甲胺Keap1/Nrf2信号通路
AtherosclerosisGut microbiome metabolitesTrimethylamine-N-oxideKeap1/Nrf2 signaling pathway
《河北医学》 2024 (6)
892-899,8
新疆维吾尔自治区卫生健康委员会青年项目,(编号:WJWY-XCZX202217)
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