槲皮素对自发性高血压大鼠血管内皮功能及主动脉纤维化的影响OACSTPCD
Effects of Quercetin on Vascular Endothelial Function and Aortic Fibrosis in Spontaneously Hypertensive Rats
目的:探讨槲皮素对自发性高血压大鼠(SHR)血管内皮功能及主动脉纤维化的影响,并初探其机制.方法:取10 只Wistar-Kyoto(WKY)大鼠设为正常组;取40 只SHR随机平均分为模型组,槲皮素低、高剂量组和卡托普利组.槲皮素低、高剂量组分别1 次/d灌胃给予50mg/kg、100mg/kg 槲皮素,卡托普利组1 次/d灌胃给予30mg/kg卡托普利,正常组和模型组1 次/d灌胃给予等体积生理盐水.连续治疗8 周后,测量大鼠血压,ELISA…查看全部>>
Objective:To investigate the effects of quercetin on vascular endothelial function and aortic fibrosis in spontaneously hypertensive rats(SHR),and to explore its possible mechanisms.Methods:Ten Wistar-Kyoto(WKY)rats were set as the normal group;forty SHRs were randomly divided into the model group,low-dose quercetin group,high-dose quercetin group,and captopril group.The low-dose and high-dose quercetin groups were administered quercetin via gavage at doses …查看全部>>
李新峰;鲁光辉;王丽斌;李晓娟
河北省邯郸市第二医院,河北 邯郸 056001河北省邯郸市第二医院,河北 邯郸 056001河北省涉县医院,河北 涉县 056400河北省邯郸市中心医院,河北 邯郸 056008
自发性高血压槲皮素内皮功能主动脉纤维化TLR4/NF-κB信号通路TGF-β1/Smad3信号通路
Spontaneous hypertensionQuercetinEndothelial functionAorta fibrosisTLR4/NF-κB signaling pathwayTGF-β1/Smad3 signaling pathway
《河北医学》 2024 (6)
905-912,8
河北省医学科学研究课题计划,(编号:20211169)
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