河北医学2024，Vol.30Issue(6)：918-923,6.DOI:10.3969/j.issn.1006-6233.2024.06.07
RDW D-二聚体炎性因子及经胸肺超声评估脓毒症患者预后的价值
The Value of RDW D-dimer Inflammatory Factors and Transthoracic Pulmonary Ultrasound in Evaluating the Prognosis of Sepsis Patients
摘要
Abstract
Objective:To explore the value of red blood cell distribution width(RDW),D-dimer(D-D),inflammatory factors,and transthoracic lung ultrasound in evaluating the prognosis of sepsis patients.Methods:A retrospective study was conducted on 98 sepsis patients treated in our hospital from January 2021 to December 2023,including 51 patients with simple sepsis and 47 patients with septic shock.There were 26 deceased patients and 72 surviving patients.Clinical data,RDW,D-D,inflammatory factors,and transtho-racic lung ultrasound differences were compared among patients with and without shock,and with different prognoses.Factors influencing patient prognosis were analyzed.Results:Sepsis shock patients had RDW,D-D,interleukin-6(IL-6),C-reactive protein(CRP),tumor necrosis factor-alpha(TNF-alpha),transtho-racic lung ultrasound B-line fusion>2 zones ratio,and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)scores of 16.68(14.12,19.55)%,3.22(2.15,7.78)mg/L,(410.03±102.21)pg/L,(32.21±11.15)mg/L,(503.74±98.87)ng/mL,70.21%,and(18.84±1.15)points,respectively,which were higher than those of simple sepsis patients(P<0.05).The age,proportion of septic shock,RDW,D-D,IL-6,CRP,TNF-alpha,transthoracic lung ultrasound B-line fusion>2 zones ratio,and A-PACHE Ⅱ scores of deceased patients were(65.51±8.22)years,76.92%,18.87(15.21,22.10)%,3.90(2.65,8.10)mg/L,(425.59±98.21)pg/L,(31.14±9.98)mg/L,(522.25±100.18)ng/ml,88.46%,and(19.11±1.43)points,respectively,which were higher than those of surviving patients(P<0.05).Logistic regression analysis showed that RDW,D-D,IL-6,CRP,TNF-alpha,transthoracic lung ultra-sound B-line fusion>2 zones ratio,and APACHE Ⅱ scores were influencing factors for patient mortality(P<0.05).The area under the ROC curve for predicting mortality in sepsis patients using the Logistic model was 0.842(95%CI:0.757-0.927),with sensitivity and specificity of 76.00%and 78.10%,respectively.Con-clusion:RDW,D-D,IL-6,CRP,TNF-alpha,and transthoracic lung ultrasound B-line fusion are related to whether sepsis patients develop shock and their prognosis,and have certain application value in predicting patient prognosis.关键词
红细胞分布宽度/D-二聚体/胸肺超声/脓毒症Key words
Red blood cell distribution width/D-dimer/Thoracopulmonary ultrasound/Sepsis引用本文复制引用
吴高飞,吴若林,陈园园,程高翔..RDW D-二聚体炎性因子及经胸肺超声评估脓毒症患者预后的价值[J].河北医学,2024,30(6):918-923,6.基金项目
2020年度安徽省自然科学基金项目,(编号:2008085QH361) （编号:2008085QH361）
