高胆红素血症新生儿血清CKMB NPY及β2-MG的水平变化及临床意义OACSTPCD

Objective:To investigate the changes and clinical significance of serum creatine kinase isoenzyme(CreatineKinase-MB,CKMB),neuropeptide Y(Neuropeptide Y,NPY),and β2-microglobulin(β2-microglobulin,β2-MG)levels in hyperbilirubinemic neonates.Methods:A total of 118 hyperbilirubi-nemic neonates admitted to our hospital from January 2019 to January 2022 were selected as the observation group.According to the total bilirubin(STB)level,they were divided into three groups:mild group(n=58,220.6μmol/L≤STB≤256.5μmol/L),moderate group(n=42,256.5μmol/L≤STB≤342μmol/L),and severe group(n=18,STB>342μmol/L).Another 112 healthy neonates without jaundice who underwent per-cutaneous bilirubin measurement in our hospital during the same period were selected as the control group.The levels of CKMB,NPY,and β2-MG in the control group and observation group were compared.The lev-els of CKMB,NPY,and β2-MG in patients with different STB levels in the observation group were compared.According to the percutaneous bilirubin-measured STB level,the patients were divided into the acute phase group and the recovery phase group,and the levels of CKMB,NPY,and β2-MG in the two groups were com-pared.Results:The levels of CKMB,NPY,and β2-MG in the observation group were all higher than those in the control group(P<0.05).Comparison of CKMB,NPY,and β2-MG levels in patients with different STB levels:mild group<moderate group<severe group(P<0.05).Among the 118 hyperbilirubinemic neonates,there were 67 cases in the acute phase group and 51 cases in the recovery phase group.The levels of CKMB,NPY,and β2-MG in the acute phase group were all higher than those in the recovery phase group(P<0.05).Conclusion:Serum CKMB,NPY,and β2-MG levels are closely related to the severity and prognosis of hyperbilirubinemia in neonates.Monitoring these indicators can help assess the progression and prognosis of the condition,providing significant clinical value.