河北医学2024，Vol.30Issue(6)：927-931,5.DOI:10.3969/j.issn.1006-6233.2024.06.09
血清ICAM-1 Hcy及MCP-1水平与视网膜静脉阻塞患者血管内皮功能的相关性
Correlation of Serum ICAM-1 Hcy and MCP-1 Levels with Vascular Endothelial Function in Patients with Retinal Vein Occlusion
摘要
Abstract
Objective:To investigate the correlation between serum intercellular adhesion molecule-1(ICAM-1),Homocysteine(Hcy),and Monocyte chemotactic protein-1(MCP-1)levels and vascular en-dothelial function in patients with retinal vein occlusion(RVO).Methods:A retrospective,double-blind method was used to analyze 95 patients with RVO admitted to our hospital from July 2020 to October 2023 as the RVO group,and 102 healthy people who underwent a physical examination in our hospital during the same period were selected as the normal control group.To compare the levels of ICAM-1,Hcy,MCP-1,vascular endothelial function[Endothelin-1(ET-1),nitric oxide(NO)]between the two groups;to compare the levels of ICAM-1,Hcy,MCP-1,ET-1 and NO in the RVO group with different types of diseases;to com-pare the levels of ICAM-1,MCP-1,ET-1 and NO in the RVO group with different degrees of diseases;and to analyze the correlation between serum levels of ICAM-1,Hcy,MCP-1 and vascular endothelial function in RVO patients.Results:Serum ICAM-1,Hcy,MCP-1,and ET-1 levels were higher and NO levels were lower in the RVO group than in the control group(P<0.05);serum ICAM-1,Hcy,MCP-1,and ET-1 lev-els were higher and NO levels were lower in the CRVO patients than in the BRVO patients(P<0.05);ICAM-1,MCP-1,and ET 1levels:mild<moderate<severe,NO levels:mild>moderate>severe(P<0.05);serum ICAM-1,Hcy,MCP-1 levels were positively correlated with ET-1 levels and negatively correlated with NO levels(P<0.05).Conclusion:Serum ICAM-1,Hcy and MCP-1 levels are all abnormally elevated in RVO patients,and are correlated with ET-1 and NO to a certain extent.Detection of serum ICAM-1,Hcy and MCP-1 levels can be used to assess the status of vascular endothelial function injury,to facilitate early treat-ment.关键词
视网膜静脉阻塞/ICAM-1/Hcy/MCP-1/血管内皮功能Key words
Retinal vein occlusion/ICAM-1/Hcy/MCP-1/Vascular endothelial function引用本文复制引用
郑博,陈丽丽..血清ICAM-1 Hcy及MCP-1水平与视网膜静脉阻塞患者血管内皮功能的相关性[J].河北医学,2024,30(6):927-931,5.基金项目
陕西省中医药管理局委托办事经费项目,(编号:2021-ZZ-JC014) （编号:2021-ZZ-JC014）
