γ-亚麻酸通过下调氧化应激反应抑制NLRP3介导的焦亡并改善脑梗塞小鼠认知障碍OACSTPCD
γ-linolenic Acid Improves Cognitive Impairment in Mice with Cerebral Infarction by Down-Regulating Oxidative Stress Response and Inhibiting NLRP3-Mediated Pyroptosis
目的:探究γ-亚麻酸(GLA)对脑梗塞小鼠认知障碍的影响及机制.方法:选取 18 只雄性小鼠,分为对照组6 只、模型组6 只和GLA组6 只,对模型组以及GLA组以大脑中动脉闭塞术进行脑栓塞小鼠认知障碍模型制作,对照组进行假手术,即手术过程相同但不插入线栓.对照组和模型组每日以1mg/kg生理盐水灌胃,GLA组每日以1mg/kg GLA灌胃14d.以Morris水迷宫评估小鼠的认知障碍情况.处死小鼠并取小鼠大脑组织,以HE 染色观察小鼠脑梗死面积…查看全部>>
Objective:To investigate the effect and mechanism of γ-linolenic acid(GLA)on cognitive impairment in mice with cerebral ischemia.Methods:Eighteen male mice were randomly divided into three groups:control group(n=6),model group(n=6),and GLA group(n=6).The cerebral infarction model was established in the model group and GLA group by middle cerebral artery occlusion(MCAO),and sham surgery was performed in the control group.Mice in the control and model groups w…查看全部>>
石剑;贡丽雅;王燕
河北医科大学第二医院营养科,河北 石家庄 050000河北医科大学第二医院营养科,河北 石家庄 050000河北医科大学第二医院营养科,河北 石家庄 050000
γ-亚麻酸氧化应激NLRP3脑梗塞认知障碍
γ-linolenic acidOxidative stressNLRP3Cerebral infarctionCognitive im-pairment
《河北医学》 2024 (6)
931-936,6
河北省2020年度医学科学研究课题计划,(编号:20200953)
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