海南医学院学报2024，Vol.30Issue(12)：881-887,7.DOI:10.13210/j.cnki.jhmu.20240326.001
血清γ-氨基丁酸、氧化应激与血脂异常的剂量-反应关系研究
Dose-response relationship between serum gamma-aminobutyric acid,oxidative stress and dyslipidemia
摘要
Abstract
Objective:To explore the dose-response relationship between γ-aminobutyric acid(GABA),markers of oxidative stress and the risk of dyslipidemia,so as to provide reference for prevention and improvement of dyslipidemia.Methods:A total of 149 patients with dyslipidemia hospitalized in a Grade A hospital in Haikou City from August 2022 to August 2023 were selected as the case group,and 236 patients with normal blood lipids were selected as the control group.The basic information of the re-search objects was collected by questionnaire.Serum GABA level,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity and malondialdehyde(MDA)level were measured by the kit.GABA and oxidative stress markers(SOD,GSH-Px,MDA)were divided into four groups according to the quartile levels of the control group from low to high(Q1 group to Q4 group).Logistic regression was used to analyze the risk of dyslipidemia.Spearman correlation coefficient,generalized linear model and restricted cubic spline were used to analyze the correlation between GABA and oxidative stress markers,and the dose-response relationship between GABA and oxidative stress markers and dyslipidemia.Results:After adjusting for confounding factors,Logistic regression showed that compared with the SOD activity,GSH-Px activity and MDA level in group Q1,the risk of dyslipidemia in the Q4 group was OR=0.537[95%CI(0.294～0.980)],OR=0.400[95%CI(0.213～0.750)]and OR=2.375[95%CI(1.254～4.495)],respectively.GABA levels were positively correlated with SOD and GSH-Px activities,and negatively correlated with MDA levels(all P<0.001).The generalized linear model and restricted cubic spline showed that the risk of dyslip-idemia decreased with the increase of SOD and GSH-Px activities,and increased with the increase of MDA levels,which was a linear dose-response relationship(all P<0.05).Conclusion:GABA level was correlated with SOD activity,GSH-Px activity and MDA level.There was a linear dose-response relationship between SOD activity,GSH-Px activity and MDA level and the risk of dyslipidemia.关键词
血脂异常/γ-氨基丁酸/氧化应激/剂量-反应关系/病例对照研究Key words
Dyslipidemia/Gamma-aminobutyric acid/Oxidative stress/Dose-response relationship/Case-control study分类
医药卫生引用本文复制引用
李彦芳,聂滢潭,韩金珂,吴菲菲,刘云儒,赵婵娟,林莉,燕贞..血清γ-氨基丁酸、氧化应激与血脂异常的剂量-反应关系研究[J].海南医学院学报,2024,30(12):881-887,7.基金项目
This study was supported by National Natural Science Foundation of China(82360636) （82360636）
Innovative Research Project of Graduate Students of Hainan Medical College(HYYB2022A23)国家自然科学基金资助项目(82360636) （HYYB2022A23）
海南医学院研究生创新科研课题(HYYB2022A23) （HYYB2022A23）
