血清γ-氨基丁酸、氧化应激与血脂异常的剂量-反应关系研究OA北大核心CSTPCD

Objective:To explore the dose-response relationship between γ-aminobutyric acid(GABA),markers of oxidative stress and the risk of dyslipidemia,so as to provide reference for prevention and improvement of dyslipidemia.Methods:A total of 149 patients with dyslipidemia hospitalized in a Grade A hospital in Haikou City from August 2022 to August 2023 were selected as the case group,and 236 patients with normal blood lipids were selected as the control group.The basic information of the re-search objects was collected by questionnaire.Serum GABA level,superoxide dismutase(SOD)activity,glutathione peroxidase(GSH-Px)activity and malondialdehyde(MDA)level were measured by the kit.GABA and oxidative stress markers(SOD,GSH-Px,MDA)were divided into four groups according to the quartile levels of the control group from low to high(Q1 group to Q4 group).Logistic regression was used to analyze the risk of dyslipidemia.Spearman correlation coefficient,generalized linear model and restricted cubic spline were used to analyze the correlation between GABA and oxidative stress markers,and the dose-response relationship between GABA and oxidative stress markers and dyslipidemia.Results:After adjusting for confounding factors,Logistic regression showed that compared with the SOD activity,GSH-Px activity and MDA level in group Q1,the risk of dyslipidemia in the Q4 group was OR=0.537[95%CI(0.294～0.980)],OR=0.400[95%CI(0.213～0.750)]and OR=2.375[95%CI(1.254～4.495)],respectively.GABA levels were positively correlated with SOD and GSH-Px activities,and negatively correlated with MDA levels(all P<0.001).The generalized linear model and restricted cubic spline showed that the risk of dyslip-idemia decreased with the increase of SOD and GSH-Px activities,and increased with the increase of MDA levels,which was a linear dose-response relationship(all P<0.05).Conclusion:GABA level was correlated with SOD activity,GSH-Px activity and MDA level.There was a linear dose-response relationship between SOD activity,GSH-Px activity and MDA level and the risk of dyslipidemia.