下调Nur77抑制PI3K/AKT信号通路促进肺腺癌细胞凋亡和自噬OA北大核心CSTPCD
Downregulation of Nur77 accelerates lung adenocarcinoma cells apoptosis and autophagy through the inhibition of the PI3K/AKT pathway
目的:探讨Nur77对肺腺癌细胞凋亡和自噬的影响及其调控机制.方法:收集右江民族医学院附属西南医院(百色市人民医院)经病理确诊的肺腺癌及癌旁组织5例,免疫荧光法检测Nur77的表达情况;生物信息学分析Nur77相关基因通路;体外培养人支气管上皮细胞BEAS-2B和人肺癌A549两株细胞系,分别记为BEAS-2B组和A549 组.RT-qPCR检测两组细胞Nur77 mRNA的表达水平,Western blot检测Nur77、LC3、PI3K、p-…查看全部>>
Objective:To investigate the role and mechanism of Nur77 in lung adenocarcinoma cell apoptosis and autophagy.Methods:Five cases of lung adenocarcinoma tissues which were confirmed by pathology and para-cancerous tissues were collected from the Affiliated Southwest Hospital of Youjiang Medical University for Nationalities(People's Hospital of Baise).The expres-sion of Nur77 in lung adenocarcinoma and para-cancerous tissues was detected with immunofluorescence…查看全部>>
莫黎芳;李小玲;韩谊;周娇;覃春艳;蒋玉洁
右江民族医学院研究生院,广西 百色 533000||百色市人民医院重症医学科,广西 百色 533000右江民族医学院研究生院,广西 百色 533000||右江民族医学院附属医院呼吸与危重症科,广西 百色 533000右江民族医学院研究生院,广西 百色 533000百色市人民医院病理科,广西 百色 533000右江民族医学院附属医院呼吸与危重症科,广西 百色 533000右江民族医学院研究生院,广西 百色 533000||右江民族医学院附属医院呼吸与危重症科,广西 百色 533000
临床医学
Nur77肺腺癌PI3K/AKT信号通路凋亡自噬
Nur77Lung adenocarcinomaPI3K/AKT pathwayAutophagyApoptosis
《海南医学院学报》 2024 (12)
897-904,8
This study was supported by the National Natural Science Foundation of China(81860021)the General Project of Guangxi Natural Science Foundation(2021GXNSFAA325003)the Research Basic Ability Improvement Project of Young and Middle-aged Teachers in Guangxi Universities(2021KY0540)the Science Research and Technology Development Plan of Baise(20193117)the Scientific Research of High-level Talents of the Scientific Research and Training of High-Level Talents(Y202011722)国家自然科学基金资助项目(81860021)广西自然科学基金项目(2021GXNSFAA325003)广西高校中青年教师科研基础能力提升项目(2021KY0540)百色市科学研究与技术开发计划(百科 20193117)右江民族医学院附属医院 2020 年度高层次人次科研项目(Y202011722)
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