军事医学2024，Vol.48Issue(6)：407-413,7.DOI:10.7644/j.issn.1674-9960.2024.06.002
裸盖菇素对小鼠社交行为调控作用研究
Regulatory effects of psilocybin on social behavior in mice
摘要
Abstract
Objective To evaluate the regulatory effects of psilocybin on social behavior of male C57BL/6J mice.Methods Adult male C57BL/6J mice were intraperitoneally injected with psilocybin(0.2,1 and 5 mg/kg,i.p.),and the effects of psilocybin on prosocial behavior were evaluated by the three-chamber test.Stressed mice undergoing chronic social defeat stress(CSDS)were given acute intraperitoneal injection of psilocybin(1 mg/kg)to evaluate the moderation of social novelty preference behavior using the modified two-chamber test.Results Intraperitoneal injection of psilocybin(1 mg/kg)promoted prosocial behavior and prolonged social time(P＜0.01),while intraperitoneal injection of psilocybin(0.2 mg/kg)had no apparent effect on the prosocial behavior of mice,and intraperitoneal injection of psilocybin(5 mg/kg)inhibited prosocial behavior before promoting it.Further studies showed that intraperitoneal injection of psilocybin(1 mg/kg)increased the social novelty exploration time in stressed mice undergoing CSDS.Conclusion This study shows that 1 mg/kg dose of psilocybin can promote the prosocial behavior in mice,and potentially ameliorate the deficit of social novelty preference behavior in CSDS mice.关键词
裸盖菇素/亲社会行为/三箱社交/两箱社交Key words
psilocybin/prosocial behavior/three-chamber test/two-chamber test分类
医药卫生引用本文复制引用
雷鑫,李燊,王禹霏,夏文龙,吴燕,赵哲,吴海涛..裸盖菇素对小鼠社交行为调控作用研究[J].军事医学,2024,48(6):407-413,7.基金项目
国家自然科学基金项目(32171148,32325025) （32171148,32325025）
科技创新2030-脑科学与类脑研究重大项目(2021ZD0202500) （2021ZD0202500）
科技部重点研发专项(2021YFA1101801) （2021YFA1101801）
