临床肝胆病杂志2024，Vol.40Issue(6)：1126-1129,4.DOI:10.12449/JCH240609
慢性乙型肝炎及肝硬化患者血清血管生成素1、2及其比值变化与HBV DNA和ALT的相关性分析
Correlation of serum angiopoietin-1,angiopoietin-2,and angiopoietin-1/angiopoietin-2 ratio with HBV DNA and alanine aminotransferase in patients with chronic hepatitis B or liver cirrhosis
摘要
Abstract
Objective To investigate the correlation of serum angiopoietin-1(Ang-1),angiopoietin-2(Ang-2),and Ang-1/Ang-2 ratio with HBA DNA and alanine aminotransferase(ALT)in patients with chronic hepatitis B(CHB)or liver cirrhosis.Methods Clinical data and serum specimens were collected from 99 patients with CHB and 59 patients with liver cirrhosis who were admitted to Beijing YouAn Hospital,Capital Medical University,from March 2018 to October 2019,and 46 individuals who underwent physical examination were enrolled as control group.PCR was used to measure serum HBV DNA level,and ELISA was used to measure the serum levels of Ang-1 and Ang-2.The serum levels of Ang-1 and Ang-2 and Ang-1/Ang-2 ratio were compared between groups.The Kruskal-Wallis H test was used for comparison of non-normally distributed continuous data between multiple groups,and the Bonferroni method was used for further comparison between two groups;the Spearman correlation analysis was used to investigate the correlation of Ang-1,Ang-2,and Ang-1/Ang-2 ratio with HBV DNA and ALT.Results Compared with the control group,the CHB group and the liver cirrhosis group had a significant reduction in the level of Ang-1(479.0 pg/mL and 208.4 pg/mL vs 671.0 pg/mL,both P＜0.05),and compared with the CHB group,the liver cirrhosis group had a significant reduction in the level of Ang-1(P＜0.001).Compared with the control group,the CHB group and the liver cirrhosis group had a significant increase in the level of Ang-2(286.1 pg/mL and 438.4 pg/mL vs 198.0 pg/mL,both P＜0.001),and compared with the CHB group,the liver cirrhosis group had a significant increase in the level of Ang-2(P＜0.001).Compared with the control group,the CHB group and the liver cirrhosis group had a significant reduction in Ang-1/Ang-2 ratio(1.6 and 0.5 vs 3.4,both P＜0.001),and compared with the CHB group,the liver cirrhosis group had a significant reduction in Ang-1/Ang-2 ratio(P＜0.001).The Spearman correlation analysis showed that in the CHB group,Ang-1 was negatively correlated with HBV DNA and ALT(r=-0.400 and-0.394,both P＜0.001),Ang-2 was positively correlated with HBV DNA and ALT(r=0.365 and 0.351,both P＜0.001),and Ang-1/Ang-2 ratio was negatively correlated with HBV DNA and ALT(r=-0.463 and-0.473,both P＜0.001);in the liver cirrhosis group,Ang-1,Ang-2,and Ang-1/Ang-2 ratio had no correlation with HBV DNA or ALT(all P＞0.05).Conclusion There are significant changes in the serum levels of Ang-1 and Ang-2 and Ang-1/Ang-2 ratio in patients with CHB or liver cirrhosis,and Ang-1,Ang-2,and Ang-1/Ang-2 ratio reflects the degree of liver injury in patients with CHB to a certain extent.关键词
血管生成素1/血管生成素2/乙型肝炎,慢性/肝硬化/乙型肝炎病毒/丙氨酸转氨酶Key words
Angiopoietin-1/Angiopoietin-2/Hepatitis B,Chronic/Liver Cirrhosis/Hepatitis B virus/Alanine Transaminase引用本文复制引用
林明华,常远,刘芳,黄雁翔,徐航飞..慢性乙型肝炎及肝硬化患者血清血管生成素1、2及其比值变化与HBV DNA和ALT的相关性分析[J].临床肝胆病杂志,2024,40(6):1126-1129,4.基金项目
北京市属医学科研院所公益发展改革试点项目(JING YI YAN 2021-10) （JING YI YAN 2021-10）
北京市工程技术研究中心(BG0320) Beijing Municipal Institute of Public Medical Research Development and Reform Pilot Project(JING YI YAN 2021-10) （BG0320）
Beijing Engineering Research Center for Precision Medicine and Transformation of Hepatitis and Liver Cancer(BG0320) （BG0320）
