T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用
Role of T-cell immunoglobulin and mucin domain-containing molecule 3 in the development and progression of liver diseases
摘要
Abstract
T-cell immunoglobulin and mucin domain-containing molecule-3(Tim-3)is a member of the Tim family and has been a research hotspot in recent years.As a negative regulatory factor,Tim-3 exerts different effects by binding to different ligands.Tim-3 is expressed in various types of immune cells,such as natural killer cells,dendritic cells,and monocytes,and Tim-3 has a regulatory effect on the functions of these immune cells.In recent years,a large number of studies have shown that Tim-3 is closely associated with the development and progression of liver diseases.This article reviews the studies on the role and mechanism of Tim-3 in different liver diseases and cells in recent years,in order to provide richer perspectives and ideas for the clinical diagnosis and treatment of liver diseases.关键词
肝疾病/T淋巴细胞免疫球蛋白黏蛋白分子3/诊断Key words
Liver Diseases/T-Cell Immunoglobulin and Mucin Domain-containing Molecule-3/Diagnosis引用本文复制引用
袁诗雨,杨焕焕,唐映梅..T淋巴细胞免疫球蛋白黏蛋白分子3在肝脏疾病发生发展中的作用[J].临床肝胆病杂志,2024,40(6):1275-1280,6.基金项目
国家自然科学基金(82360108) （82360108）
云南省医学领军人才项目(L-2019013) （L-2019013）
云南万人计划(YNWR-MY-2018-028) （YNWR-MY-2018-028）
中国联合肝脏健康促进中心-戊型肝炎防治专项基金(CLH2023-F-HEV-08) （CLH2023-F-HEV-08）
云南省科技人才与平台计划(院士专家工作站202305AF150065) （院士专家工作站202305AF150065）
昆明医科大学第二附属医院临床研究项目(2020ynlc010,ynIIT2021017) National Natural Science Foundation of China(82360108) （2020ynlc010,ynIIT2021017）
Yunnan Medical Leading Talent Project(L-2019013) （L-2019013）
Yunnan Ten Thousand Talents Project(YNWR-MY-2018-028) （YNWR-MY-2018-028）
China United Liver Health Promotion Center-Special Fund for Hepatitis E Prevention and Treatment(CLH2023-F-HEV-08) （CLH2023-F-HEV-08）
Yunnan Provincial Science and Technology Talent and Platform Program(Academician Expert Workstation 202305AF150065) （Academician Expert Workstation 202305AF150065）
Clinical Research Project of the Second Affiliated Hospital of Kunming Medical University(2020ynlc010,ynIIT2021017) （2020ynlc010,ynIIT2021017）
