临床肝胆病杂志2024，Vol.40Issue(6)：1281-1288,8.DOI:10.12449/JCH240633
IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值
Mechanism of action and potential value of the IRE1α/TRAF2/JNK pathway in the progression of acute liver failure
摘要
Abstract
Acute liver failure(ALF)is one of the most critical liver diseases in clinical practice and seriously affects the life and health of Chinese people.Due to its high morbidity and mortality rates,unclear pathogenesis,and limited treatment methods,ALF has become a major problem that needs to be solved urgently in the field of liver diseases.In recent years,more and more studies have shown that endoplasmic reticulum stress is a key biological process in the progression of ALF,and the IRE1α/TRAF2/JNK pathway,as a part of endoplasmic reticulum stress signaling,plays a role in amplifying inflammatory response,promoting hepatocyte apoptosis,and inhibiting liver regeneration ability during the progression of diseases.As a traditional treasure of China,traditional Chinese medicine has become a research hotspot in search for effective prevention and treatment drugs for ALF from monomers of Chinese herbs.This article elaborates on the mechanism of action of the IRE1α/TRAF2/JNK pathway in the progression of ALF and summarizes the potential value of several monomers of Chinese herbs in regulating this pathway,such as salidroside,Fructus Broussonetiae,Fructus Psoraleae+Schisandra chinensis,baicalein,genipin,kaempferol,resveratrol,sea buckthorn polysaccharide extract,and luteol,in order to provide a reference for further research and clinical practice of ALF.关键词
肝功能衰竭,急性/信号传导/内质网应激Key words
Liver Failure,Acute/Signal Transduction/Endoplasmic Reticulum Stress引用本文复制引用
关海梅,张衎,陈玮钰,李国宝,曾阳玲,张日云,王恬雯,谢宝华,毛德文..IRE1α/TRAF2/JNK信号通路在急性肝衰竭发展中的作用机制及潜在价值[J].临床肝胆病杂志,2024,40(6):1281-1288,8.基金项目
国家自然科学基金(82274434,81960841,82060848) （82274434,81960841,82060848）
广西中医药大学研究生教育创新计划(YCBZ2023157) National Natural Science Foundation of China(82274434,81960841,82060848) （YCBZ2023157）
Guangxi University of Traditional Chinese Medicine Graduate Education Innovation Program(YCBZ2023157) （YCBZ2023157）
