激光技术2024，Vol.48Issue(3)：312-317,6.DOI:10.7510/jgjs.issn.1001-3806.2024.03.003
基于OCT高危人群糖尿病筛查方法
Method of diabetes screening in high-risk population based on OCT
摘要
Abstract
In order to screen potential diabetes patients in high-risk groups,a non-invasive screening method for diabetes in high-risk groups based on optical coherence tomography(OCT)is proposed,and the patients could be early treated and reduce complications.This method first divided the 3-D OCT image into many small regions.Due to the different correlations between blood glucose changes and scattering coefficients in different regions,the principal component analysis was used to transform the scattering coefficients of these blood glucose sensitive regions into a comprehensive indicator S.Then S was normalized at different times of 0 min～120 min to obtain the relative quantity Si(i=0,1,2,…,120),with a relative quantity of S120 at 120 min.According to the experience value of normalized blood glucose of healthy subjects,moderate diabetes,and severe diabetes in 0 min～120 min,the judgment threshold 1 and threshold 2 is 0.47 and 0.78,respectively.If 0<S120<0.47,0.47<S120<0.78,and 0.78<S120<1,the subject is healthy,moderate diabetes and severe diabetes,respectively.This method is high practicability and has great significance for screening diabetes in high-risk groups with optical non-invasive methods.关键词
医用光学/生物技术/无创血糖检测/光学相干层析成像/糖尿病筛查/主成分分析Key words
medical optics/biotechnology/noninvasive blood glucose detection/optical coherence tomography/diabetes screening/principal component analysis分类
电子信息工程引用本文复制引用
何松,苏亚,姚晓天,郝鹏,崔省伟,蔡开明,孙金豪..基于OCT高危人群糖尿病筛查方法[J].激光技术,2024,48(3):312-317,6.基金项目
国家自然科学基金资助项目(62105091) （62105091）
河北省重点研发计划资助项目(20542201D) （20542201D）
河北省自然科学基金资助项目(F2020201041 （）
F2021201016) （）
河北大学自然科学多学科交叉研究计划资助项目(DXK202204) （DXK202204）
