环境与职业医学2024，Vol.41Issue(6)：593-600,8.DOI:10.11836/JEOM23387
全氟化合物暴露与中老年女性血脂水平的关联
Associations of per-and poly-fluoroalkyl substances exposure with blood lipids in middle-aged and elderly women
摘要
Abstract
[Background]Per-and poly-fluoroalkyl substances(PFAS)are a class of emerging persistent or-ganic pollutants,and their negative health impacts have been widely concerned.There is a lack of epidemiological studies on the associations of PFAS exposure with lipid homeostasis. [Objective]To investigate the associations of perfluorooctanesulfonic acid(PFOS)and perfluo-rooctanoic acid(PFOA)exposure with blood lipid levels and dyslipidemia in middle-aged and el-derly women. [Methods]This study was based on 795 middle-aged and elderly women from a female sub-cohort of the Dongfeng-Tongji cohort study,excluding the participants without blood lipid measurements and/or reported use of lipid-lowering drugs at baseline.The concentrations of plasma PFOS and PFOA were measured by ultra-high performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS).The concentrations of serum total cholesterol(TC),triglyceride(TG),high-density lipoprotein cholesterol(HDL-C),and low-density lipoprotein cholesterol(LDL-C)were measured using an automatic analyzer.The normally distributed continuous variables were presented as mean±standard deviation((¯x)±s),while the skewedly distributed continuous variables were presented as median(M)and the 25th and 75th percentiles(P25,P75).Generalized linear models(GLM),generalized additive models(GAM),and logistic regression models were applied to evaluate the associations of PFOS and PFOA exposure with blood lipid levels and the risk of dyslipidemia.Stratified analyses were also implemented to explore potential modification effects of sociodemographic characteristics,lifestyles,and menopause on asso-ciations of PFOS and PFOA exposure and blood lipids. [Results]The (¯x)±s of baseline age for the study participants was(59.4±8.6)years old,and their baseline body mass index(BMI)was(24.3±3.4)kg·m-2.The M(P25,P75)of baseline plasma concentrations for PFOS and PFOA were 9.96(6.24,15.09)μg·L-1 and 1.20(0.84,1.80)μg·L-1 respectively.The GLM analysis showed that plasma concentration of PFOS was positively associated with serum HDL-C[b(95％CI):0.04(0.01,0.07)].The plasma concentration of PFOA was also positively associated with serum TC[b(95％CI):0.05(0.02,0.08)]and serum LDL-C[b(95％CI):0.05(0.01,0.09)].No significant association was observed between plasma PFOS and serum TC,TG,or LDL-C,nor between plasma PFOA and serum TG or HDL-C.The stratified analyses showed that the association between PFOA and LDL-C was significant among the participants aged<60 years old[b(95％CI):0.06(0.01,0.11),P=0.014].A modification effect was observed for age on the as-sociation of plasma PFOA with serum LDL-C,with Pinteraction=0.046.The analysis of the associations between PFOS/PFOA exposure and the risk of dyslipidemia showed that an increased plasma PFOA was significantly associated with an increased risk of hypercholesterolemia,with an OR(95％CI)of 1.69(1.23,2.15).No association was observed between PFOS exposure and the risk of dyslipidemia. [Conclusion]This cross-sectional study reveals that common PFAS exposure could affect the homeostasis of blood lipids based on the fe-male sub-cohort of the Dongfeng-Tongji cohort,which provides new evidence for the negative health impact of PFAS.关键词
全氟化合物/全氟辛基磺酸/全氟辛酸/血脂/血脂异常/女性Key words
per-and poly-fluoroalkyl substances/perfluorooctanesulfonic acid/perfluorooctanoic acid/blood lipid/dyslipidemia/female分类
医药卫生引用本文复制引用
游潆茜,冯越,付铭,郭欢..全氟化合物暴露与中老年女性血脂水平的关联[J].环境与职业医学,2024,41(6):593-600,8.基金项目
国家自然科学基金创新群体项目(82021005) （82021005）
