健脾补肾益视方对小鼠干性年龄相关性黄斑变性的保护作用及其机制OACSTPCD
Protective effect of Jianpi Bushen Yishi formula on dry age-related macular degeneration in mice and its mechanism
目的:探讨健脾补肾益视方对碘酸钠诱导的小鼠干性年龄相关性黄斑变性(dARMD)的保护作用及其机制. 方法:将27只SPF级雄性C57BL/6小鼠随机分为空白组、模型组和中药组,每组各9只,通过苏木精-伊红(HE)染色观察视网膜的结构形态,二氢乙锭(DHE)荧光染色观察小鼠视网膜细胞内活性氧(ROS)水平,生化试剂盒检测小鼠视网膜丙二醛(MDA)、超氧化物歧化酶(SOD)表达水平,Western blot检测小鼠视网膜沉默信息调节因子相关蛋白1(S…查看全部>>
AIM:To investigate the protective effect of Jianpi Bushen Yishi Formula on dry age-related macular degeneration(dARMD)induced by sodium iodate in mice and its mechanism. METHODS:A total of 27 SPF male C57BL/6 mice were randomly divided into blank,model and traditional Chinese medicine groups,with 9 in each group,the structure and morphology of the retina were observed by Hematoxylin-Ehong(HE)staining,and the intracellular reactive oxygen species(ROS)in the r…查看全部>>
李妍;牟琳;陈廷
(646000)中国四川省泸州市,西南医科大学附属中医医院眼科(646000)中国四川省泸州市,西南医科大学附属中医医院眼科(646000)中国四川省泸州市,西南医科大学附属中医医院眼科
健脾补肾益视方干性年龄相关性黄斑变性(dARMD)氧化应激SIRT1/PGC-1α蛋白
Jianpi Bushen Yishi formuladry age-related macular degeneration(dARMD)oxidative stressSIRT1/PGC-1α protein
《国际眼科杂志》 2024 (7)
1032-1037,6
四川省中医药管理局科学技术研究专项课题(No.2021MS455) Sichuan Provincial Administration of Traditional Chinese Medicine Science and Technology Research Special Project(No.2021MS455)
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