国际眼科杂志2024，Vol.24Issue(7)：1073-1077,5.DOI:10.3980/j.issn.1672-5123.2024.7.12
细胞外基质在年龄相关性黄斑变性中的研究进展
Research progress of extracellular matrix in age-related macular degeneration
摘要
Abstract
Age-related macular degeneration(ARMD)is the leading cause of blindness in the elderly.Studies have shown that the regulation disorder of extracellular matrix(ECM)is one of the important characteristics of ARMD,and its damage can be sustained throughout the disease course.Additionally,various cell types participate in the formation and abnormal deposition of ECM under the control of multiple signals.Subsequently,they transmit signals that regulate adhesion,migration,proliferation,apoptosis,survival or differentiation,which lead to the destruction of the retinal and choroidal microenvironment,immune dysfunction,infiltrative inflammatory cell differentiation,neovascularization and epithelial mesenchymal transformation,and ultimately lead to subretinal fibrosis,scarring and severe visual impairment in advanced ARMD.Therefore,increasing attention has been paid to the role of ECM in ARMD in recent years.This article reviews the relationship between retinal ECM and ARMD and the role between ECM and various types of cells in ARMD,hoping to provide guidance for the research direction of ARMD treatment.关键词
年龄相关性黄斑变性/细胞外基质/脉络膜新生血管/视网膜下纤维化/视网膜色素上皮细胞/成纤维细胞/小胶质细胞/巨噬细胞Key words
age-related macular degeneration/extracellular matrix/choroidal neovascularization/subretinal fibrosis/retinal pigment epithelium cell/fibroblast/microglia/macrophage引用本文复制引用
杨宁,徐新荣..细胞外基质在年龄相关性黄斑变性中的研究进展[J].国际眼科杂志,2024,24(7):1073-1077,5.基金项目
国家自然科学基金面上项目(No.82074177,82374214) National Natural Science Foundation of China(No.82074177,82374214) （No.82074177,82374214）
