辽宁大学学报（自然科学版）2024，Vol.51Issue(2)：97-102,6.
依鲁替尼(Ibrutinib)合成路线图解
Diagram of Synthesis Routes for Ibrutinib
摘要
Abstract
Ibrutinib is a Bruton's tyrosine kinase(BTK)inhibitor jointly developed by Pharmacyclics and Janssen Biotech.Ibrutinib is the first small molecule drug targeting BTK for the treatment of sleeve cell lymphoma.This article summarizes the synthesis process of Ibrutinib,in order to provide new ideas for the design of Ibrutinib synthesis routes.关键词
依鲁替尼/合成路线/布鲁顿酪氨酸激酶(BTK)抑制剂/抗肿瘤药物Key words
Ibrutinib/synthesis route/Bruton's tyrosine kinase(BTK)inhibitor/antitumor drug分类
医药卫生引用本文复制引用
刘举,金凡琪,车晋,高俊峰,李春艳,陈烨,周云鹏..依鲁替尼(Ibrutinib)合成路线图解[J].辽宁大学学报（自然科学版）,2024,51(2):97-102,6.基金项目
国家自然科学基金青年科学基金项目(21807055) （21807055）
沈阳市自然科学基金项目(23-503-6-12) （23-503-6-12）
