国际眼科杂志2024，Vol.24Issue(7)：1173-1178,6.DOI:10.3980/j.issn.1672-5123.2024.7.32
新型冠状病毒感染相关急性黄斑区神经视网膜病变的神经眼科特征
Neuro-ophthalmic features of SARS-CoV-2 associated acute macular neuroretinopathy
摘要
Abstract
AIM:To explore the neuro-ophthalmological characteristics of acute macular neuroretinopathy(AMN)after SARS-CoV-2 infection. METHODS:A total of 8 patients(14 eyes),including 6 females and 2 males,who were diagnosed with AMN in the neuro-ophthalmology department of Xi'an No.1 Hospital(The First Affiliated Hospital of Northwest University)from December 27,2022 to February 1,2023 were included in the study.All patients had a history of SARS-CoV-2 infection before the disease,and the results of best corrected visual acuity(BCVA),non-contact indirect intraocular pressure measurement,fundus color photography,near infrared(IR),spectral-domain optical coherence tomography(SD-OCT),OCT angiography(OCTA),fundus fluorescein angiography(FFA),indocyanine green angiography(ICGA),visual field,visual evoked potential(VEP),and electroretinogram(ERG)were collected.Furthermore,the neuro-opthalmology characteristics of the included patients were analyzed and summarized. RESULTS:The included 8 patients aged from 20 to 43,with an average age of(30±6.63)years old.The patients had a history of SARS-CoV-2 infection 3 to 11(mean 5±3.51)d before the disease,and 6 out of 8 patients developed visual symptoms within 5 d of infection with SARS-CoV-2,with manifestated with decreased vision or visual scotoma.The visual acuity varied from 0.08 to 1.0,with visual field defect characterized by central,paracentral or peripheral scotoma.VEP showed prolongation latency of P100 or P2,and ERG revealed impaired function of retinal photoreceptor cell.In the early stage of the disease,the size and shape of early visual acuity,visual field,and extraretinal lesions in patients with AMN associated with SARS-CoV-2 infection may not match,and the lower the visual acuity,the later the VEP peaks. CONCLUSION:The neuro-ophthalmic features of SARS-CoV-2 infection-associated AMN require the attention of clinicians.In addition to multi-mode fundus imaging,clinicians should use a variety of methods to comprehensively evaluate visual function and prognosis of patients.关键词
新型冠状病毒/急性黄斑区神经视网膜病变/光学相干断层扫描/多模式影像/神经眼科Key words
SARS-CoV-2/acute macular neuroretinopathy/optical coherence tomography/multimodal imaging/neuro-ophthalmology引用本文复制引用
刘佩,储昭节,李波,蔺雪梅,刘燕,宋沉生,索琰,赵隽,吴松笛..新型冠状病毒感染相关急性黄斑区神经视网膜病变的神经眼科特征[J].国际眼科杂志,2024,24(7):1173-1178,6.基金项目
陕西省科技计划项目(No.2022SF-381,2023-YBSF-048,2022SF-507,2023-YBSF-052) （No.2022SF-381,2023-YBSF-048,2022SF-507,2023-YBSF-052）
陕西省中医药管理局项目(No.2022-SLRH-LJ-013) （No.2022-SLRH-LJ-013）
西安市科技计划项目(No.22YXYJ0061,22YXYJ0074) （No.22YXYJ0061,22YXYJ0074）
西安市科协青年人才托举计划项目(No.095929221312) Science and Technology Program of Shaanxi Province(No.2022SF-381,2023-YBSF-048,2022SF-507,2023-YBSF-052) （No.095929221312）
Project of Shaanxi Administration of Traditional Chinese Medicine(No.2022-SLRH-LJ-013) （No.2022-SLRH-LJ-013）
Science and Technology Program of Xi'an(No.22YXYJ0061,22YXYJ0074) （No.22YXYJ0061,22YXYJ0074）
Project of Science and Technology Association of Xi'an Young Talent Lifting Program(No.095929221312) （No.095929221312）
