四川精神卫生2024，Vol.37Issue(3)：226-231,6.DOI:10.11886/scjsws20230916001
阿立哌唑联合奥氮平治疗住院男性精神分裂症患者的效果及对代谢综合征的影响
Efficacy of aripiprazole combined with olanzapine for hospitalized male patients with schizophrenia and its effect on metabolic syndrome
摘要
Abstract
Background Schizophrenia and the use of antipsychotic medications are identified to be the likely contributors to the development of metabolic syndrome(MS)and cardiovascular disease,and jeopardize the prognosis of schizophrenia.Therefore,effectively preventing or reducing the risk of developing MS in patients with schizophrenia is critical.Objective To explore the efficacy of aripiprazole combined with olanzapine for male schizophrenia patients and its effect on MS,so as to provide a certain reference for the selection of antipsychotic drugs for schizophrenia patients.Methods Male patients(n=80)who were hospitalized in The Third People's Hospital of Meizhou from February to June 2023 and fulfilling the International Classification of Diseases,tenth edition(ICD-10)diagnostic criteria for the schizophrenia were enrolled,and grouped using random number table method,each with 40 cases.Study group was treated with aripiprazole combined with olanzapine,while control group was given aripiprazole monotherapy.The treatment lasted for 6 continuous weeks in both groups.At the baseline,Positive and Negative Symptom Scale(PANSS)score,MS-related indices[fasting plasma glucose(FPG),hemoglobin A1c(HbA1c),body mass index(BMI),waist-to-hip ratio(WHR),lipid profile],S100 calcium-binding protein B(S100B)and high sensitivity C-reactive protein(hs-CRP)were recorded.Then the PANSS scores at the end of the 2nd,4th and 6th week of treatment,the Clinical Global Impression(CGI)scores at the end of the 2nd and 6th week of treatment,as well as the MS-related indices,S100B,hs-CRP,Treatment Emergent Symptom Scale(TESS)score and Rating Scale for Extrapyramidal Side Effects(RSESE)score at the end of the 6th week of treatment were recorded in all participants.Results Analysis on PANSS score revealed a significant group effect,time effect and group×time interaction effect(F=18.092,634.780,2.917,P<0.05 or 0.01).Analysis on CGI score revealed a significant group effect and time effect(F=20.492,99.190,P<0.01).At the end of the 6th week of treatment,study group detected lower serum concentrations of HbA1c and triglyceride(TG)compared with control group(t=-3.495,-3.293,P<0.05).The post-treatment hs-CRP level was lower in study group than that in control group(t=-3.916,P<0.05).Study group scored lower on TESS compared with control group(t=-4.684,P<0.01).Conclusion Aripiprazole combined with olanzapine can effectively alleviate psychotic states in male schizophrenia patients,and the combination therapy yields less impact on MS-related indices than olanzapine monotherapy.关键词
精神分裂症/男性/阿立哌唑/奥氮平/代谢综合征Key words
Schizophrenia/Male/Aripiprazole/Olanzapine/Metabolic syndrome分类
临床医学引用本文复制引用
刘舜华,袁小凤,叶雪婷,张瑜良,赵莉,周坤元..阿立哌唑联合奥氮平治疗住院男性精神分裂症患者的效果及对代谢综合征的影响[J].四川精神卫生,2024,37(3):226-231,6.基金项目
梅州市科技计划项目(项目名称:使用阿立哌唑片联合非典型抗精神病药干预精神分裂症代谢异常的研究,项目编号:2022B116) Funded by Meizhou Science and Technology Plan Project(number,2022B116) （项目名称:使用阿立哌唑片联合非典型抗精神病药干预精神分裂症代谢异常的研究,项目编号:2022B116）
