摘要
Abstract
Objective:To analyze the distribution characteristics of human papillomavirus(HPV)genotypes in male pa-tients with condyloma acuminatum(CA),and explore the relevant risk factors for recurrence in CA patients after CO2 laser treatment,in order to provide evidence for the prevention and treatment of CA and CA carcinogenesis.Methods:256 CA pa-tients admitted to the Skin Disease Center of Suining Hospital from January 2018 to June 2023 were selected as the research subjects.HPV genotyping was performed for the skin lesions of all patients.All patients received CO2 laser combined with imiquimod.They were followed up for 3 months and assigned to the cured group and the recurrence group.At the same time,demographic characteristics,lifestyle,sexual behavior,disease and other data of the patients were collected.Univariate and multivariate binary logistic regression analyses were used to screen the risk factors that affect the recurrence of CA after CO2 laser treatment.Results:Among the 256 male CA patients,there were 110 cases of single infection(42.97％)and 146 ca-ses of mixed infection(57.03％).The low-risk HPV(LR-HPV)subtype was the main subtype in single infection cases(105 cases,95.45％),while low-and high-risk mixed subtype was the main subtype in mixed infection cases(135 cases,92.47％).The top 5 genotypes were LR-HPV6,LR-HPV11,high-risk HPV(HR-HPV)16,HR-HPV82 and HR-HPV58,with the proportions of 30.65％,19.35％,8.43％,5.56％and 3.83％,respectively.Multivariate binary logistic regression analysis showed that smoking(OR=2.654,P=0.001),staying up late(OR=2.957,P=0.001),number of sexual partners ≥ 3(OR=8.867,P=0.001),duration of disease＞6 months(OR=6.328,P＜0.001),skin lesions ≥ 2 parts(OR=5.701,P＜0.001)and HR-HPV infection(OR=6.079,P＜0.001)were independent risk factors for recurrence in male CA patients treated by CO2 laser.Conclu-sion;The dominant subtypes of HPV infection in male CA patients in this region are LR-HPV6,LR-HPV11,HR-HPV16,HR-HPV82 and HR-HPV58.The risk factors for recurrence include smoking,staying up late,multiple sexual partners,long-term illness,multiple skin lesions and HR-HPV infection.关键词
男性/尖锐湿疣/人乳头瘤病毒/复发/危险因素Key words
Male/Condyloma acuminate/Human papillomavirus/Recurrence/Risk factors分类
医药卫生
