肿瘤预防与治疗2024，Vol.37Issue(6)：525-535,11.DOI:10.3969/j.issn.1674-0904.2024.06.011
空间分割放疗技术的应用及研究进展
Advances in Application and Research of Spatially Fractionated Radiation Therapy
摘要
Abstract
External beam radiation therapy is the primary modality of radiotherapy,and has significantly enhanced the u-niformity and accuracy of tumor dosing.However,these advances have also introduced a high risk of toxicity to surrounding organs,which,to some extent,limits further im-provements in the therapeutic efficacy of radiotherapy.In con-trast,spatially fractionated radiation therapy(SFRT)delivers a highly heterogeneous dose to tumors,is a strategy that has demonstrated remarkable efficacy in treating large metastatic and primary tumors,while effectively reducing the high toxicity risk to organs at risk.The successful implementation of SFRT greatly relies on technological advancements,particularly on modulation capabilities,which have propelled its transition from two-dimensional grid therapy to three-dimensional lattice therapy.Proton/heavy ion therapy and microbeam/minibeam therapy represent the latest physical technological applications in SFRT.This article aims to review the implementation methods,phys-ical and dosimetric characteristics of SFRT,and explore its applications and research progress in radiotherapy.This review hopes to provide valuable insights for clinical practice and technological research,thereby promoting further development and application of SFRT in the field of radiotherapy.关键词
空间分割放疗/网格放疗/点阵放疗Key words
Spatially fractionated radiation therapy/Grid radiation therapy/Lattice radiation therapy分类
医药卫生引用本文复制引用
袁珂,兰美,姚杏红,廖雄飞,徐鹏,阴骏,郎锦义,王先良..空间分割放疗技术的应用及研究进展[J].肿瘤预防与治疗,2024,37(6):525-535,11.基金项目
This study was supported by grants from University of Electronic Science and Technology(No.ZYGX2021YGCX0002),Key Laboratory of Radiation Physics and Technology,Ministry of Education(No.2023SCURPT05)and Science and Technology Department of Sichuan Province(No.2023YFS0157). 中央高校基本科研业务费专项资金(编号:ZYGX2021YGCX002) （No.ZYGX2021YGCX0002）
辐射物理及技术教育部重点实验室开放课题(编号:2023SCURPT05) （编号:2023SCURPT05）
四川省科技厅重点研发项目(编号:2023YFS0157) （编号:2023YFS0157）
