四川精神卫生2024，Vol.37Issue(3)：270-276,7.DOI:10.11886/scjsws20231002002
脑电信号在焦虑障碍疗效预测与治疗机制中的研究进展
Research progress on electroencephalography in the prediction of efficacy and therapeutic mechanism for anxiety disorders
摘要
Abstract
Anxiety disorders are characterized by high prevalence and recurrence rate.Selective serotonin reuptake inhibitors(SSRIs)and cognitive behavioral therapy(CBT)are recommended as first-line treatments for anxiety disorders,while some patients do not response to either of these treatments.Therefore,exploring the neurobiological mechanisms associated with treatment response and valuable prognostic marker is of great value in guiding clinical decision making.Previous studies have reported an altered electroencephalogram(EEG)pattern in patients with anxiety disorders after treatment,and revealed a correlation between baseline EEG and treatment response,suggesting that EEG is of great value in predicting the treatment response in anxiety disorders.The purpose of this article is to delineate findings from a systematic review of the literature investigating the EEG signal in prognostic prediction and exploration of neurobiological mechanisms,so as to provide electrophysiological evidence for individualized treatment of anxiety disorders.Results of this review show that patients responding more strongly to negative emotional stimuli before treatment are more likely to benefit from SSRIs and CBT.After the CBT,no statistical difference is found in the amplitude of error-related negativity(ERN)and P1 component between pre-and post-procedure measurements,suggesting that CBT may not reduce anxiety symptoms by improving attention bias and behavioral monitoring.EEG indicators related to emotion perception under negative emotional stimuli at baseline,such as late positive potential(LPP),may be promising markers for predicting response to treatment in anxiety disorders.关键词
焦虑障碍/脑电图/疗效/预测Key words
Anxiety disorders/Electroencephalogram/Treatment response/Prediction分类
医药卫生引用本文复制引用
袁丹凤,杨祥云,李占江..脑电信号在焦虑障碍疗效预测与治疗机制中的研究进展[J].四川精神卫生,2024,37(3):270-276,7.基金项目
Funded by the Science and Technology Innovation 2030-Major Project of"Brain Science and Brain-like Research"(number,2021ZD0202004) （number,2021ZD0202004）
Capital Health Development Scientific Research Project(number,2020-1-2121) 科技创新2030-"脑科学与类脑研究"重大项目(项目名称:焦虑障碍复发技术与新型综合干预模式研究,项目编号:2021ZD0202004) （number,2020-1-2121）
首都卫生发展科研专项(项目名称:惊恐障碍针灸治疗方案优化及相关脑功能研究,项目编号:2020-1-2121) （项目名称:惊恐障碍针灸治疗方案优化及相关脑功能研究,项目编号:2020-1-2121）
