食管疾病2024，Vol.6Issue(2)：102-106,5.DOI:10.15926/j.cnki.issn2096-7381.2024.02.003
高原地区低剂量食管癌根治性放疗后放射性肺炎影响因素分析
Influencing Factors of Radiation Pneumonia after Low Dose Radical Radiotherapy for Esophageal Cancer in Plateau Area
摘要
Abstract
Objective To analyze the factors influencing the occurrence of radiation pneumonia(RP)after radical radiotherapy for esophageal cancer in plateau area under the background of low dose based on longitudinal cohort.Methods A retrospective analysis was conducted on the data of 172 esophageal cancer patients who underwent radical radiotherapy at our hospital from July 2020 to June 2023.RP was rated ac-cording to the National Cancer Institute Common Adverse Reaction Terminology Evaluation Standard 5.0(CT-CAE 5.0).Clinical factors,traditional independent dosimetry characteristics and dose-interval variation char-acteristics were collected.Correlation analysis was performed for the features used to predict the occurrence of symptomatic RP,feature screening was performed with structural clustering,multi-factor analysis was per-formed with logisitc regression(LR),and visualization was performed with Python.Results The incidence of RP was 81 cases(47.09％)in 172 patients,including 53 cases(30.8％)in grade 1,13 cases(7.5％)in grade 2,12 cases(6.9％)in grade 3,and 3 cases(1.7％)in grade 4.123 patients(71.51％)received a low dose of≤50.4 Gy;Multivariate a-nalysis showed that physical strength score(PS),interstitial pneumonia(IP),and prescribed dose(plan_dose)were independent prognostic factors for RP.Conclusion Radical radiotherapy for esopha-geal cancer in plateau area is safe under low dose background,and the radiotherapy dose should be carefully determined for patients with poor physical scores and prior interstitial pneumonia.关键词
高原地区/食管癌/放射治疗/剂量学、放射性肺炎Key words
plateau region/esophageal cancer/radiotherapy/dosimetry/radiation pneumonia分类
医药卫生引用本文复制引用
赵冬梅,王丽,柏晗,卢飞,李岚,夏耀雄..高原地区低剂量食管癌根治性放疗后放射性肺炎影响因素分析[J].食管疾病,2024,6(2):102-106,5.基金项目
2023年云南省兴滇英才计划"青年人才"项目 （）
