世界中医药2024，Vol.19Issue(8)：1192-1196,1202,6.DOI:10.3969/j.issn.1673-7202.2024.08.022
针刺调控缺氧诱导因子-1α信号通路改善缺血性脑血管病的作用机制
Mechanism of Acupuncture Regulating HIF-1α Signaling Pathway to Ameliorate Ischemic Cerebrovascular Disease
摘要
Abstract
Ischemic cerebrovascular disease is one of the common nervous system diseases with a high disability rate and high mor-tality,which has aggravated the economic burden of health worldwide.Hypoxia-inducible factor(HIF-1α)is a key factor in re-sponse to hypoxia,playing an important role in the occurrence and development of ischemic cerebrovascular disease.Acupuncture has demonstrated significant advantages in the treatment of this disease.Acupuncture may regulate the HIF-1α signaling pathway to exert the therapeutic effect,which may be the main mechanism.Studies have shown that the regulatory effect of acupuncture on HIF-1α may be related to not only the type of injury but also the time effect of HIF-1α expression and the timing of acupuncture in-tervention.关键词
缺氧诱导因子-1α/缺血性脑血管疾病/针刺/脑梗死/缺血再灌注/血管再生/神经保护/综述Key words
Hypoxia-inducible factor-1α/Ischemic cerebrovascular disease/Acupuncture/Cerebral infarction/Ischemia reperfu-sion/Revascularization/Neuroprotection/Review分类
医药卫生引用本文复制引用
姜海伦,朱巍明,张超,孟祥刚,李姗姗,孟智宏..针刺调控缺氧诱导因子-1α信号通路改善缺血性脑血管病的作用机制[J].世界中医药,2024,19(8):1192-1196,1202,6.基金项目
国家自然科学基金项目(8220153095) （8220153095）
