子午流注法温灸联合穴位贴敷治疗功能性便秘的疗效观察OACSTPCD

Objective To observe the clinical efficacy of Zi Wu Liu Zhu(midnight-noon ebb-flow)acupoint gentle moxibustion plus application of self-prescribed Ruan Jian San at Shenque(CV8)for functional constipation and its effect on serum motilin(MTL)and 5-hydroxytryptamine 4 receptor(5-HT4R)levels in the patients.Method Eighty patients with functional constipation were allocated,using a random number table,to a control group and a study group,with 40 cases in each group.The control group was treated with Zi Wu Liu Zhu acupoint gentle moxibustion and the study group received application of self-prescribed Ruan Jian San at Shenque in addition.The clinical therapeutic effects were compared between the two groups.The symptom score,rectal pressure,as well as serum MTL,5-HT4R,neuronal nitric oxide synthase(nNOS),nitric oxide(NO),vasoactive intestinal polypeptide(VIP),superoxide dismutase(SOD),malondialdehyde(MDA)and glutathione(GSH)levels were observed in the two groups before and after treatment.Result The total efficacy rate was significantly higher in the study group than in the control group(P＜0.05).After treatment,serum MTL and 5-HT4R levels increased in the two groups compared with those before treatment(P＜0.05)and were higher in the study group than those in the control group(P＜0.05).After treatment,the clinical symptom score,and serum nNOS,NO and VIP levels decreased in the two groups compared with those before treatment(P＜0.05)and were lower in the study group than those in the control group(P＜0.05).After treatment,the rectoanal inhibitory reflex threshold and the first defecation sensory threshold decreased(P＜0.05)and the maximum compression pressure and rectal resting pressure increased(P＜0.05)in the two groups compared with those before treatment;the above indicators were better in the study group than those in the control group(P＜0.05).After treatment,serum MDA levels decreased(P＜0.05)and SOD and GSH levels increased(P＜0.05)in the two groups compared with those before treatment;the above indicators were better in the study group than those in the control group(P＜0.05).Conclusion On the basis of conventional treatment,Zi Wu Liu Zhu acupoint gentle moxibustion plus application of self-prescribed Ruan Jian San at Shenque is clinically more effective than gentle moxibustion alone in treating functional constipation.It can increase serum MTL and 5-HT4R levels,relieve the clinical symptoms and rectal pressure and improve serum intestinal neurotransmitter,SOD,MDA and GSH levels.