柴芩承气汤干预急性胰腺炎的配伍规律及作用机制OA北大核心CHSSCDCSTPCD

Objective:To investigate the clinical effect and mechanism of Chaiqin Chengqi Decoction with different compatibility in treating acute pancreatitis(AP).Methods:KM mice were randomly assigned into 6 groups(n=10):blank control,model,and Chaiqin Chengqi Decoction A,B,C,and D.The mouse model of AP was established by intraperitoneal injection of 20％L-arginine.The mice in Chaiqin Chengqi Decoction A,B,C,and D groups were administrated with Chaiqin Chengqi Decoction with different compatibility(crude drug concentration of 1 g/mL)by gavage twice a day for 3 consecutive days.At the time point of 72 h after modeling,the body-to-pancreas ratio and the amylase(AMS)level in the serum were measured,and the pathological changes of the pancreas were observed.The levels of malondialdehyde(MDA)and superoxide dismutase(SOD)in the serum were measured.Re-sults:Chaiqin Chengqi Decoction with different compatibility reduced the body-to-pancreas ratio,alleviated the edema,bleeding,and necrosis of the pancreas,lowered the levels of AMS and MDA,and elevated the level of SOD in the serum of AP mice.Further-more,group A performed the best in mitigating the pancreatic edema and recovering the serum MDA level of AP mice.Group B showcased the best performance in alleviating the pathological damage in the pancreas and recovering the serum AMS level.Group D demonstrated the best performance in restoring the serum SOD level.Conclusion:Chaiqin Chengqi Decoction with different com-patibility alleviated the pancreatic damage in AP mice,with the varied effects due to different compatibility.