上海针灸杂志2024，Vol.43Issue(6)：701-708,8.DOI:10.13460/j.issn.1005-0957.2023.13.0032
电针上肢穴位对运动皮层躯干脑区皮质脊髓兴奋性的影响
Effect of electroacupuncture at upper limb points on corticospinal excitability in the motor cortex of brain region of trunk
摘要
Abstract
Objective To observe the effect of electroacupuncture at upper limb points on corticospinal excitability in the primary motor cortex(M1)of the brain region of the trunk in healthy subjects.Method Fifteen healthy subjects were recruited to conduct a cross-over design trial.Trial part 1 observed the effect of electroacupuncture at upper limb points on corticospinal excitability of the erector spinae(ES).The subjects randomly joined three test groups:group A received electroacupuncture at Hegu(LI4),group B at Kongzui(LU6),and group C at the sham Hegu point.Before and after the intervention,transcranial magnetic stimulation(TMS)was used to detect the contralateral M1 of the first dorsal interosseus,flexor carpi radialis,and ES for the amplitude and latency of motor evoked potentials(MEPs).Those with increased amplitude of ES MEPs were selected for test part 2.Test part 2 studied the influence of EA at upper limb points on the corticospinal excitability of ES after inhibiting the dorsal premotor cortex(PMd).The subjects randomly joined two test groups:group D received electroacupuncture at Hegu plus inhibiting PMd,and group E received electroacupuncture at Kongzui plus inhibiting PMd.The contralateral M1 in brain regions of the upper limbs and trunk was observed for the amplitude and latency of MEPs.Result After the intervention,the total amplitude of MEPs in brain regions of the upper limbs and trunk increased significantly in groups A and B(P＜0.001,P＜0.01).After the intervention,Group A surpassed group C in comparing the total amplitude of MEPs in brain regions of the upper limbs and trunk,while group B only showed an advantage in comparing the total amplitude of MEPs in the brain region of the trunk compared with group C,all showing statistical significance(P＜0.001).The mean and total amplitudes of MEPs increased markedly at the optimal stimulation spot in the brain region of upper limbs in group D after the intervention(P＜0.05).Neither group D nor group E showed significant changes in the mean and total amplitudes of MEPs at the optimal stimulation spot in the brain region of the trunk after the intervention(P＞0.05).Conclusion Under physiological conditions,electroacupuncture at either Hegu or Kongzui can enhance ES's corticospinal excitability,showing no significant differences,and PMd may play a role in the process.关键词
针刺疗法/电针/脑可塑性/运动诱发电位/皮质脊髓兴奋性/经颅磁刺激/穴,合谷/穴,孔最Key words
Acupuncture therapy/Electroacupuncture/Brain plasticity/Motor evoked potentials/Corticospinal excitability/Transcranial magnetic stimulation/Point,Hegu(LI4)/Point,Kongzui(LU6)分类
医药卫生引用本文复制引用
程伟丽,周彤,黄键澎,谢萌萌,许能贵,刘健华..电针上肢穴位对运动皮层躯干脑区皮质脊髓兴奋性的影响[J].上海针灸杂志,2024,43(6):701-708,8.基金项目
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202004) （ZYYCXTD-C-202004）
国家自然科学基金面上项目(81873381) （81873381）
广东省岭南中医药重点研发项目(2020B1111100008) （2020B1111100008）
