世界中医药2024，Vol.19Issue(9)：1316-1323,8.DOI:10.3969/j.issn.1673-7202.2024.09.017
中医药治疗肺癌的用药规律
Medication Rules of TCM in Treating Lung Cancer
摘要
Abstract
Objective:To investigate the medication rules of TCM in treating lung cancer.Methods:The TCM prescriptions for treating lung cancer were retrieved from The Complete Collection of Tumor Prescriptions,The Dictionary of Tumor Prescriptions,The Ministry of Health Drug Standard of Chinese Medicine Formulation,and The Promulgation of National Drug Standard(Revi-sion).The data were entered into Excel for data processing,and Lantern 5.0,SPSS Modeler 18.0,and SPSS Statistics 25.0 were used for the frequency statistics,hierarchical cluster analysis,and association rule analysis of the prescriptions.Results:A total of 650 prescriptions were collected,involving 572 Chinese medicines which had the total frequency of 6 120.The Chinese medicines used in the prescriptions mainly had cold,warm,and plain natures,bitter,sweet,and pungent flavors,and tropism to the stomach,spleen,kidney,liver,and lung meridians.The most frequently used Chinese medicines were Astragali Radix,Hedyotidis Herba,Gly-cyrrhizae Radix et Rhizoma,Poria,Adenophorae Radix,and Ophiopogonis Radix.The high-frequency Chinese medicines mainly had the effects of clearing heat and removing toxin,replenishing qi and nourishing yin,and activating blood and resolving stasis.The as-sociation rule analysis yielded 16 pair associations and 24 triple associations of Chinese medicines,and 13 common factors were ob-tained within factors.The hierarchical cluster analysis yielded 7 closely associated medicine combinations.The latent structure anal-ysis yielded 14 latent variables,each with 2 latent classes,totaling 28 latent classes.Conclusion:The TCM treatment of lung canc-er,which is based on the principles of tonifying qi and nourishing yin,clearing heat and removing cancer toxin,activating blood and resolving stasis,invigorating the spleen and draining dampness,and clearing heat and resolving phlegm,remains to be validated by clinical and experimental studies.关键词
中医药/肺癌/方剂/药组/用药规律/数据挖掘/系统聚类分析/关联规则分析Key words
TCM/Lung cancer/Prescription/Medicine combination/Medication rules/Data mining/Hierarchical cluster analy-sis/Association rule analysis分类
中医学引用本文复制引用
辛静,蒋士卿,张云慧,周月玲,孙旭杭,王留芳..中医药治疗肺癌的用药规律[J].世界中医药,2024,19(9):1316-1323,8.基金项目
国家重大科技专项(2013ZX10005001001007) （2013ZX10005001001007）
河南省科技攻关项目(212102311125) （212102311125）
河南省重点项目(豫发改高技[2020]701-115) （豫发改高技[2020]701-115）
河南省中医药科学研究重大专项(2019ZYZD06) （2019ZYZD06）
