Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear InflammationOACSTPCD
Andrographolide Attenuates Noise-Induced Hearing Loss by Ameliorating Cochlear Inflammation
Objective:This study aimed to explore andrographolide's mechanism of action and its protective effect on noise-induced hearing loss(NIHL).Materials and Methods:A mice animal model for NIHL was established through exposure to broadband noise at 120 dB sound pressure level for 4 h.Transcriptomics analysis and pharmacodynamic experiments were carried out.Results:Andrographolide enters the inner ear and effectively prevents hearing damage following noise exposure in the mice model for permanent hearing loss.Moreover,treatment with andrographolide inhibited the excessive activation of inflammatory factors in the cochleae of noise-exposed mice.Conclusion:Andrographolide might be a promising candidate for auditory protective drug investigation.
Meng-Hua Li;Yun-Shi Zhang;He Sun;Xiao-Hui Ma;Xi Shi;Wan-Qi Wang;Li-Ting Zheng;Meng-Bing Chen;Yang Chu;Miao Qiao;Zuo-Li Zhang;Konduru Naveena;Yong Pan
Artificial Auditory Laboratory of Jiangsu Province,Xuzhou Medical University,Xuzhou,China||Key Laboratory of Tropical Biological Resources of Ministry of Education,School of Pharmaceutical Sciences,Hainan University,Haikou,China||Department of ENT,Beijing Friendship Hospital,Capital Medical University,Beijing,ChinaDepartment of Respiratory Medicine,Xuzhou Infectious Diseases Hospital,Affiliated Hospital of Xuzhou Medical University,Xuzhou,ChinaNational Key Laboratory of Chinese Medicine Modernization,Tasly Academy,Tasly Pharmaceutical Group Co.,Ltd.,Tianjin,ChinaArtificial Auditory Laboratory of Jiangsu Province,Xuzhou Medical University,Xuzhou,China||Key Laboratory of Tropical Biological Resources of Ministry of Education,School of Pharmaceutical Sciences,Hainan University,Haikou,China||Department of ENT,The People's Hospital of Rongchang District,Chongqing,ChinaArtificial Auditory Laboratory of Jiangsu Province,Xuzhou Medical University,Xuzhou,ChinaEndoscopy Center,Ankang People's Hospital,Ankang,China
Andrographolideanti-inflammatoryauditory protectionnoise-induced hearing losstraditional Chinese medicine compound
《世界中医药杂志（英文版）》 2024 (002)
204-212 / 9
This work was supported by the Science and Technology Development Aid Project of Xuzhou Science and Technology Bureau(KC21249),the Science and Technology Development Project of Chongqing(CSTB2022NSCQ-M SX1598),Hainan Provincial Natural Science Foundation of China(824MS052),TASLY Special Funding 2023,and the Scientific Research Startup Foundation of Hainan University.
评论