灵芝多糖对糖尿病肾病小鼠的改善作用及机制研究OA北大核心CSTPCD
Study on the improvement effect and mechanism of Ganoderma lucidum polysaccharides on diabetic nephropathy in mice
研究了灵芝多糖(Ganoderma lucidum polysaccharide,GLP)对糖尿病肾病(diabetic nephropathy,DN)小鼠的作用.成功构建DN小鼠模型后GLP干预.检测小鼠空腹血糖和24 h尿蛋白含量,测定尿素氮(blood urea nitrogen,BUN)和肌酐(serum creatinine,Scr)水平,结合伊红和马松染色观察肾脏病理形态,采用酶联免疫吸附试验测定肿瘤坏死因子 α(tumor necr…查看全部>>
The study investigated the effects of Ganoderma lucidum polysaccharide(GLP)on diabetic nephropathy(DN)in mice.After successfully establishing a DN mouse model,GLP intervention was administered.The fasting blood glucose and 24-hour urinary protein content of the mice were measured,and the levels of blood urea nitrogen(BUN)and serum creatinine(Scr)were determined.Eosin and Masson's trichrome staining were used to observe the renal pathological morphology.En-zy…查看全部>>
马广礼;夏晓培
许昌职业技术学院医疗卫生学院,许昌 461000许昌职业技术学院医疗卫生学院,许昌 461000
中医学
灵芝多糖RAGE信号糖尿病肾病炎症
Ganoderma lucidum polysaccharideRAGE signalingdiabetic nephropathyinflammation
《天然产物研究与开发》 2024 (6)
938-945,8
河南省高等教育教学改革研究与实践项目(2019SJGLX716)
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