天然产物研究与开发2024，Vol.36Issue(6)：963-967,5.DOI:10.16333/j.1001-6880.2024.6.006
野菊中一个新的吉马烷型倍半萜
A new gemmarane-type sesquiterpenoid from Chrysanthemum indicum L.
摘要
Abstract
To study the chemical constituents of the aboveground of Chrysanthemum indicum L.All compounds were separated and purified by MCI,ODS,SephadexLH-20 gel column chromatography and pre-HPLC,and the structures of them were identi-fied by analyzing of their spectroscopic data.Compounds 1-6 were isolated from the dichloromethane extract of C.indicum,which were identified as chrygermalide A(1),3β-hydroxy-oxo-7α,11β-germacra-4Z,10(14)-diene-12,6α-olide(2),deacetylherbolide A(3),9β-hydroxy costunolide(4),3β-hydroxycostunolide(5),3β-hydroxy-11α,13-dihydrocos-tunolide(6).Compound 1 is a new compound,and 2-6 are isolated from this genus for the first time.The anti-inflammatory activity of compounds 1-6 were tested in LPS-induced RAW 264.7 macrophage cells,and the IC50 values of their NO release inhibition were 17.9-33.9 μmol/L.关键词
野菊/化学成分/倍半萜类/抗炎活性Key words
Chrysanthemum indicum L./chemical constituents/sesquiterpenoid/anti-inflammatory activity分类
医药卫生引用本文复制引用
潘浩,薛金凤,贾瑶瑶,卢纪衡,袁雨洁,冯卫生,吴亚,薛贵民..野菊中一个新的吉马烷型倍半萜[J].天然产物研究与开发,2024,36(6):963-967,5.基金项目
国家自然科学基金(82003606) （82003606）
河南省高校科技创新团队支持计划(24IRTSTHN039) （24IRTSTHN039）
