补骨脂醇提物UPLC-Q-TOF-MS化学成分分析及促黑色素生成作用机制初探OA北大核心CSTPCD
Chemical composition analysis of Psoraleae Fructus alcohol extract by UPLC-Q-TOF-MS and its mechanisms of promoting melanogenesis
分析补骨脂醇提物(Psoraleae Fructus alcohol extract,PFE)化学成分并探讨其促黑色素生成作用机制.采用超高效液相色谱-四级杆飞行时间质谱(UPLC-Q-TOF-MS)对PFE化学成分进行鉴定;观察PFE对斑马鱼黑色素生成的影响;通过实时荧光定量聚合酶链式反应(quantitative real-time PCR,qRT-PCR)考察PFE、补骨脂素和异补骨脂素对小鼠黑色素瘤细胞B16-F10中酪氨酸酶(tyros…查看全部>>
This study aims to analyze the chemical constituents of Psoraleae Fructus ethanol extract(PFE)and explore its mechanism of promoting melanin production.The chemical constituents of PFE were analyzed and identified by ultra perform-ance liquid chromatography-quadrupole-time of flight-mass spectrometry(UPLC-Q-TOF-MS)technology.Zebrafish was used to investigate the effects of PEF on the melanogenesis.The regulation effects of PFE,psoralen and isopsoralen on the…查看全部>>
何婷;王银洁;詹莹莹;莫婷;杨丽娟;杨森
宁夏回族医药研究所,银川 750021宁夏医科大学附属银川市中医医院,银川 750001广州中医药大学第二临床医学院,广州 510006宁夏回族医药研究所,银川 750021宁夏回族医药研究所,银川 750021宁夏回族医药研究所,银川 750021
药学
补骨脂醇提物黑色素UPLC-Q-TOF-MS补骨脂素异补骨脂素
Psoraleae Fructus alcohol extractmelaninUPLC-Q-TOF-MSpsoralenisopsoralen
《天然产物研究与开发》 2024 (6)
968-981,953,15
宁夏自然科学基金(2023AAC03717)宁夏青年科技人才托举工程项目(2020-78)宁夏回族自治区卫生健康委员会2023年度科研项目(2023-NWKYP-038)
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