汕头大学医学院学报2024，Vol.37Issue(2)：67-70,4.DOI:10.13401/j.cnki.jsumc.2024.02.002
髓源性抑制细胞相关抗原在垂体瘤中的表达
Expression of myeloid-derived suppressor cells-associated antigens in pituitary tumor
摘要
Abstract
Objective:To investigate the expression of myeloid-derived suppressor cells(MDSCs)-associated antigens in pituitary tumor.Methods:Twenty-six patients with pituitary tumors(pituitary tumor group),including 16 cases of invasive pituitary tumors and 10 cases of non-invasive pituitary tumors,who attended the Second Affiliated Hospital of Shantou University Medical College from 2012 to 2022 were selected.In addition,10 patients with craniocerebral trauma or cerebral hemorrhage requiring internal decompression surgery were collected as the control group during the same period.There were 19 males and 7 females in the pituitary tumor group,with a mean age of(52±18)years.In the control group,there were 7 males and 3 females with a mean age of(51±19)years.The expression of MDSCs-related antigens CD11b,CD15 and IL-4Rα in the tumor tissues of patients with pituitary tumors and the brain tissues of patients in the control group were detected by immunofluorescence staining,respectively.Results:The fluorescence intensity of CD11b+,CD15+,CD11b+CD15+myeloid-derived granulocytes in pituitary tumors was higher than that in the control group,and the difference was statistically significant(all P<0.05).The fluorescence intensity of CD11b+,CD15+,CD11b+CD15+myeloid-derived granulocytes in invasive pituitary tumor tissues was higher than that of the non-invasive group(all P<0.05).IL-4Rα was not expressed in pituitary tumors and brain tissues.Conclusion:MDSCs-associated antigens CD11b,CD15 and CD11b+CD15+myeloid-derived granulocytes are expressed at elevated levels in pituitary tumors,especially invasive pituitary tumors.关键词
垂体瘤/髓源性抑制细胞/CD11b/CD15Key words
pituitary tumor/myeloid-derived suppressor cells/CD11b/CD15分类
医药卫生引用本文复制引用
杨文鹏,陈式仪,田飞,杨少锋,陈文荣..髓源性抑制细胞相关抗原在垂体瘤中的表达[J].汕头大学医学院学报,2024,37(2):67-70,4.基金项目
广东省医学科研基金(B2022038) （B2022038）
