汕头大学医学院学报2024，Vol.37Issue(2)：85-89,5.DOI:10.13401/j.cnki.jsumc.2024.02.006
儿童EB病毒DNA与肺炎的相关因素分析
Analysis of the correlation factors between EB virus DNA and pneumonia in children
摘要
Abstract
Objective:To investigate the correlation between Epstein-Barr virus(EBV)DNA and pneumonia in children,and to improve clinicians' understanding of the diagnosis and treatment of EBV-infected children.Methods:612 EBV-DNA-positive children hospitalized in Huizhou Central People's Hospital and Huizhou First Maternal and Child Health Care Hospital from May 2021 to April 2023 were retrospectively selected,and 1,178 EBV-DNA-negative children hospitalized during the same period were collected as the control group.EBV-DNA-positive children were divided into the pneumonia group(n=242)and the non-pneumonia group(n=347)according to the presence or absence of combined pneumonia,and logistic regression analyses were used to explore the correlation between EBV-DNA and pneumonia in children.Results:Among 612 EBV-DNA-positive children,the male to female ratio was 1.35:1.The age of onset was 3 months to 13 years,with 21 cases(3.4%)in infancy,136 cases(22.2%)in toddlerhood,319 cases(52.1%)in preschool,and 136 cases(22.2%)in school-age,and the peak age of the patients was in preschool.The number of EBV-DNA-positive combined pneumonias was 242 cases(39.5%),of which 15 cases(2.5%)developed severe pneumonia.The difference between EBV-DNA-positive and negative children with combined pneumonia was statistically significant(P<0.05).Logistic regression analysis showed that compared to the normal body temperature,the OR value of the maximum temperature range of 37.3 to<38℃was 6.165,and the OR values of hepatomegaly,white blood cell count and complement C3 were 3.525,0.952,and 4.605,respectively(all P<0.05).Conclusion:The distribution of EBV-DNA-positive children varies in different age groups,and maximum body temperature,hepatomegaly,white blood cell count,and complement C3 are correlates of EBV-DNA-positive combined pneumonia.关键词
EB病毒DNA/肺炎/儿童Key words
Epstein-Barr virus DNA/pneumonia/child分类
医药卫生引用本文复制引用
吴志勇,吴显劲,杨坤祥..儿童EB病毒DNA与肺炎的相关因素分析[J].汕头大学医学院学报,2024,37(2):85-89,5.基金项目
惠州市科技计划项目(2021WC0106210) （2021WC0106210）
