心理科学进展2024，Vol.32Issue(7)：1031-1047,17.DOI:10.3724/SP.J.1042.2024.01031
应激下人类情景记忆巩固的神经重放机制
The neural replay mechanisms of episodic memory consolidation under stress in humans
摘要
Abstract
Memory consolidation typically occurs slowly during rest or sleep periods following memory encoding.Under stress,though,the consolidation of memories may accelerate considerably.The mechanisms underlying this rapid memory consolidation in stressful circumstances remain unclear,primarily due to the longstanding absence of quantitative methodologies for investigating the neural activities during the human memory consolidation.This research aims to employ computational neuroscience techniques to meticulously characterize neural replay during the consolidation of episodic memory under stress.Specifically,we propose an integrated approach involving cognitive psychology,neuroimaging,machine learning,neuroendocrine regulation,stress induction,and physiological and neuroendocrine assessments to examine the'double-edged sword'hypothesis related to stress and neural replay.Although stress might hasten the rate of neural replay,thereby facilitating memory consolidation,it could simultaneously compromise the accuracy of neural replay and disrupt its sequentiality.Our study will:(1)juxtapose the multi-dimensional characteristics of neural replay under stress and non-stress conditions;(2)probe the interplay between neural replay and memory retrieval and encoding in stressful conditions;and(3)strive to employ neuroendocrine and environmental tactics to modulate human stress responses,which in turn could influence neural replay during consolidation.The implications of this research are twofold:it could help identify the optimal brain state to enhance memory consolidation and bridge the gap between human and animal studies on neural replay.At the same time,it could illuminate new strategies for preserving episodic memory function under stress and intervening in memory deficits seen in stress-associated psychiatric disorders.关键词
记忆巩固/记忆提取/应激/神经重放/情景记忆Key words
memory consolidation/memory retrieval/acute stress/neural replay/episodic memory分类
社会科学引用本文复制引用
刘威,陈瑞欣,郭金朋..应激下人类情景记忆巩固的神经重放机制[J].心理科学进展,2024,32(7):1031-1047,17.基金项目
国家自然科学基金青年项目(32300879),教育部人文社科基金青年项目(22YJCZH109),湖北省自然科学基金青年项目(2022CFB793),认知神经科学与学习国家重点实验室开放课题基金(CNLYB2103),青少年网络心理与行为教育部重点实验室开放课题基金(CCNUCYPSYLAB2022B10)资助. （32300879）
