摘要
Abstract
Objective To compare the clinical effect of low dose sequential increase and constant dose of Letrozole in the treatment of polycystic ovary syndrome(PCOS)infertility,and to provide reference for clinical medication.Methods A total of 40 patients with PCOS infertility admitted to Hezhang County People's Hospital from March to October 2023 were selected as the research objects,and they were divided into observation group(22 cases)and control group(18 cases)by random lottery method.The observation group was treated with low dose of Letrozole sequential increase,and the control group was treated with constant dose of Letrozole.The days of follicle maturation,endometrial thickness on the day of human chorionic gonadotropin(HCG),the number of dominant follicles,the number of follicles≥18 mm on the day of HCG,and the incidence of biochemical pregnancy,clinical pregnancy,and spontaneous abortion were compared between the two groups.Results There were no significant differences in the days of follicle maturation and endometrial thickness on the day of HCG between the two groups(P>0.05).The number of follicles≥18 mm on the day of HCG and dominant follicles in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).There were no statistically significant differences in biochemical pregnancy rate,clinical pregnancy rate,and spontaneous abortion rate between the two groups(P>0.05).Conclusion Letrozole low dose sequential increase therapy for PCOS infertility can reduce the number of follicles≥18 mm on the day of HCG and dominant follicles,which is a more feasible ovulation induction scheme.关键词
多囊卵巢综合征/不孕症/来曲唑/序贯递增/诱导排卵Key words
Polycystic ovary syndrome/Infertility/Letrozole/Sequentially increase/Induced ovulation分类
医药卫生
