外科理论与实践2024，Vol.29Issue(2)：93-98,6.DOI:10.16139/j.1007-9610.2024.02.01
系统疗法改变肝癌外科的格局:机遇与挑战
Systemic therapy alters the landscape of surgery in hepatocellular carcinoma:opportunities and challenges
邵卫清 1陆录 1钦伦秀1
作者信息
- 1. 复旦大学附属华山医院普外科 肝胆外科中心,复旦大学肿瘤转移研究所,上海 200040
- 折叠
摘要
Abstract
Surgery is still the first choice for patients with hepatocellular carcinoma(HCC).However,about 70%of HCC patients in China are first diagnosed in the advanced stage and have lost the opportunity for surgery.Recently,the rapid development of systematic therapy has brought new hope for patients with advanced HCC.The combination of molecular targeted therapy and immunotherapy with or without local therapy significantly improves the survival of advanced HCC and alters the landscape of surgical treatment in advanced HCC.In addition,systemic therapy also brings new opportunities for perioperative treatment of HCC patients.Conversion therapy,neoadjuvant therapy,and postoperative adjuvant therapy can increase the chances of surgical treatment,reduce the risk of postoperative metastasis and recurrence,and prolong the overall survival of HCC patients.Systematic therapy based on molecular targeted therapy and immunotherapy has been applied through the whole process of HCC surgical treatment,and has completely altered the surgery paradigm of HCC.However,further research is needed to determine the optimal combination protocol,screen the sensitive populations,address drug resistance,and reduce systemic adverse events.关键词
肝细胞癌/系统治疗/转化治疗/新辅助治疗/辅助治疗Key words
Hepatocellular carcinoma(HCC)/Systemic therapy/Conversion therapy/Neoadjuvant therapy/Adjuvant therapy分类
医药卫生引用本文复制引用
邵卫清,陆录,钦伦秀..系统疗法改变肝癌外科的格局:机遇与挑战[J].外科理论与实践,2024,29(2):93-98,6.
