外科理论与实践2024，Vol.29Issue(2)：114-120,7.DOI:10.16139/j.1007-9610.2024.02.04
胆道恶性肿瘤分型新进展
Recent advances in subtyping of biliary tract carcinoma
林志文 1刘红枝 1曾永毅2
作者信息
- 1. 福建医科大学孟超肝胆医院肝胆外科,福建 福州 350025||福建省肝病科学研究中心,福建 福州 350025
- 2. 福建医科大学孟超肝胆医院肝胆外科,福建 福州 350025||福建省肝病科学研究中心,福建 福州 350025||福建医科大学附属第一医院肝胆外科,福建 福州 350005
- 折叠
摘要
Abstract
Biliary tract carcinoma exhibits high heterogeneity at the genomic,epigenetic,and molecular expression levels.The patients even with the same pathological morphology and clinical stage of biliary tract malignant tumors have substantial differences in the treatment response and prognosis.Traditional pathological histology and clinical classifications are no longer sufficient to meet the demands of the precision medicine era.Molecular subtyping has the potential to provide more personalized cancer treatment strategies.It not only helps to reveal the mechanisms of tumor development and accurately predict disease prognosis,but also plays a crucial role in guiding the development of novel targeted drugs and implementing targeted therapies for specific tumors.With the ongoing development of precision medicine,the role of molecular subtyping in cancer diagnosis,treatment option,and prognosis assessment is increasingly prominent.This paper systematically reviewed the recent progress in the molecular subtyping of biliary tract malignant tumors based on domestic and international clinical and basic research.关键词
胆道恶性肿瘤/临床分型/病理组织学分型/分子分型/精准治疗Key words
Biliary tract carcinoma/Clinical classification/Pathological histology classification/Molecular subtyping/Precision therapy分类
医药卫生引用本文复制引用
林志文,刘红枝,曾永毅..胆道恶性肿瘤分型新进展[J].外科理论与实践,2024,29(2):114-120,7.
