中风与神经疾病杂志2024，Vol.41Issue(6)：533-538,6.DOI:10.19845/j.cnki.zfysjjbzz.2024.0102
血清PGC-1α和FNDC5水平与高血压性脑出血患者病情程度及预后的相关性分析
Association of the serum levels of peroxisome proliferator-activated receptor-γ coactivator-1α and fibronectin type Ⅲ domain-containing protein 5 with the severity and prognosis of patients with hypertensive cerebral hemor-rhage
摘要
Abstract
Objective To investigate the serum levels of peroxisome proliferator-activated receptor-γ coactivator-1α(PGC-1α)and fibronectin type Ⅲ domain-containing protein 5(FNDC5)in patients with hypertensive cerebral hemor-rhage and their association with disease severity and prognosis.Methods A total of 80 patients with hypertensive cere-bral hemorrhage who were diagnosed and treated in our hospital from July 2019 to February 2022 were enrolled as case group,and 80 individuals undergoing physical examination were enrolled as control group.ELISA was used to measure the serum levels of PGC-1α and FNDC5,and the receiver operating characteristic(ROC)curve was used to investigate their value in predicting the prognosis of patients with hypertensive cerebral hemorrhage.The logistic regression analysis was used to investigate the influencing factors for poor prognosis in patients with hypertensive cerebral hemorrhage.Results The case group had significantly lower serum levels of PGC-1α and FNDC5 than the control group(P<0.05),and the good prognosis group also had significantly higher serum levels of PGC-1α and FNDC5 than the poor prognosis group.Disease severity,PGC-1α,and FNDC5 were influencing factors for poor prognosis in patients(P<0.05).Serum PGC-1α and FNDC5 alone or in combination had an area under the ROC curve of 0.957,0.937,and 0.985,respec-tively,in predicting poor prognosis in patients with hypertensive cerebral hemorrhage.Conclusion There are low expres-sion levels of PGC-1α and FNDC5 in patients with hypertensive cerebral hemorrhage,which are associated with the sever-ity and prognosis of patients.Both of them are independent protective factors for prognosis and have a certain application value in evaluating prognosis in clinical practice.关键词
高血压性脑出血/PGC-1α/FNDC5Key words
Hypertensive cerebral hemorrhage/Peroxisome proliferator-activated receptor-γ coactivator-1α/Fibronectin type Ⅲ domain-containing protein 5分类
医药卫生引用本文复制引用
蔡一帆,刘诚林,李兵,丁嘉圣,盛豪..血清PGC-1α和FNDC5水平与高血压性脑出血患者病情程度及预后的相关性分析[J].中风与神经疾病杂志,2024,41(6):533-538,6.基金项目
2018年度苏州市临床重点病种诊疗技术专项项目(LCZX201821) （LCZX201821）
