中风与神经疾病杂志2024，Vol.41Issue(6)：539-543,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0103
NO/ET-1比值、LDL/ApoB比值与急性缺血性脑卒中后早期神经功能恶化的相关性研究
Association of nitric oxide/endothelin-1 ratio and low-density lipoprotein/apolipoprotein B ratio with early neuro-logical deterioration after acute ischemic stroke
摘要
Abstract
Objective To investigate the association of nitric oxide(NO)/endothelin-1(ET-1)ratio and low-density lipoprotein(LDL)/apolipoprotein B(ApoB)ratio with early neurological deterioration(END)after acute ischemic stroke(AIS).Methods A retrospective analysis was performed for the clinical data of 108 AIS patients who were admit-ted to Mianyang Hospital Affiliated to University of Electronic Science and Technology School of Medicine&Mianyang Central Hospital from March 2021 to March 2023,and the incidence rate of END within 24 hours after disease onset was analyzed.Laboratory data were collected to calculate NO/ET-1 ratio and LDL/ApoB ratio.A binary logistic regression analysis was used to analyze the influencing factors for END after AIS,and the receiver operating characteristic(ROC)curve was used to investigate the value of NO/ET-1 ratio and LDL/ApoB ratio in identifying END after AIS.Results END was observed in 23 patients,and the END group had significantly lower NO/ET-1 ratio and LDL/ApoB ratio than the non-END group(P<0.05).High NHISS score on admission and diabetes were risk factors for END after AIS(P<0.05),while NO/ET-1 ratio and LDL/ApoB ratio were protective factors(P<0.05).NO/ET-1 ratio and LDL/ApoB ratio had and area under the ROC curve(AUC)of 0.737 and 0.753,respectively,in predicting END after AIS,and NO/ET-1 ratio com-bined with LDL/ApoB ratio had an AUC of 0.900 in predicting END after AIS,suggesting that NO/ET-1 ratio combined with LDL/ApoB ratio had a significantly higher AUC than NO/ET-1 ratio or LDL/ApoB ratio alone(P<0.05).Conclusion The reductions in NO/ET-1 ratio and LDL/ApoB ratio in AIS patients are associated with the onset of END,and the combination of NO/ET-1 ratio and LDL/ApoB ratio has a higher value in predicting END after AIS.关键词
急性缺血性脑卒中/早期神经功能恶化/脑血管反应性/一氧化氮/内皮素-1/低密度脂蛋白/载脂蛋白BKey words
Acute ischemic stroke/Early neurological deterioration/Cerebral vasomotor reactivity/Nitric oxide/Endothelin-1/Low-density lipoprotein/Apolipoprotein B分类
医药卫生引用本文复制引用
喻洪,刘丹,朱伦刚..NO/ET-1比值、LDL/ApoB比值与急性缺血性脑卒中后早期神经功能恶化的相关性研究[J].中风与神经疾病杂志,2024,41(6):539-543,5.基金项目
四川省卫生健康委员会科研课题(19PJ113) （19PJ113）
