中风与神经疾病杂志2024，Vol.41Issue(6)：555-559,5.DOI:10.19845/j.cnki.zfysjjbzz.2024.0106
COX1基因多态性与血小板聚集功能在缺血性脑卒中复发患者中的交互作用
Interaction between COX1 gene polymorphism and platelet aggregation function in patients with recurrent isch-emic stroke
刘星亮 1范磊 1娄展 1宋征宇1
作者信息
- 1. 河北北方学院附属第一医院神经内科,河北 张家口 075000
- 折叠
摘要
Abstract
Objective To investigate the influence of the interaction between COX1 gene polymorphism and plate-let aggregation function on patients with recurrent ischemic stroke.Methods A total of 70 patients with recurrent isch-emic stroke from July 2020 to July 2023 were enrolled as observation group,and 70 healthy individuals who underwent physical examination during the same period of time were enrolled as control group.General data were compared between the two groups,and COX1 gene polymorphism was analyzed.The distribution of genotype and allele frequencies at COX1 gene polymorphism loci was determined and compared between the two groups.Platelet aggregation rate and its association and interaction with the susceptibility to recurrence of ischemic stroke were compared between the patients with different genotypes in the observation group.Results There were significant differences between the two groups in platelet count,COX1,and platelet aggregation rate(P<0.05).There were also significant differences between the two groups in the fre-quencies of CC gene,CT gene,and TT gene and the distribution of genotype C and genotype T at the rs1330344 locus of the COX1 gene(P<0.05).The risk of the recurrence of ischemic stroke in the patients who carried genotype CC at the rs1330344 locus of the COX1 gene was 1.872 times that in the patients who did not carry this genotype.In the observation group,the patients with genotype CC at the rs1330344 locus of the COX1 gene had the highest platelet aggregation rate,fol-lowed by those with genotype CT and genotype TT(P<0.05).The genotype at the rs1330344 locus of the COX1 gene was sig-nificantly correlated with platelet aggregation rate.The history of diabetes and hypertension,triglyceride,homocysteine,geno-type at the rs1330344 locus of the COX1 gene,and platelet aggregation rate were independent risk factors for recurrence of isch-emic stroke(P<0.05).There was a positive interaction between genotype CC at the rs1330344 locus of the COX1 gene and platelet aggregation rate in the susceptibility to recurrence of ischemic stroke(3.266<1.736×2.114,which was a sub-multiplicative model).Conclusion There is a positive interaction between genotype CC at the rs1330344 locus of the COX1 gene and platelet aggregation rate in the susceptibility to recurrence of ischemic stroke,and there is a significant increase in sus-ceptibility.Therefore,early prevention measures can be developed in clinical practice.关键词
COX1/基因多态性/血小板聚集/缺血性脑卒中复发Key words
COX1/Genetic polymorphism/Platelet aggregation/Recurrence of ischemic stroke分类
医药卫生引用本文复制引用
刘星亮,范磊,娄展,宋征宇..COX1基因多态性与血小板聚集功能在缺血性脑卒中复发患者中的交互作用[J].中风与神经疾病杂志,2024,41(6):555-559,5.
