泛素-蛋白酶体系统与神经系统疾病的研究进展OACSTPCD
Research progress on ubiquitin-proteasome system and nervous system diseases
泛素-蛋白酶体系统(UPS)是一种内部蛋白质分解机制,是细胞一系列生命过程的重要调节器,可处理大部分细胞的蛋白质周转,可去除老化、损坏和错误折叠的蛋白质,与各种疾病的发生发展密切相关.近年来各个领域对该系统的研究已渐渐成为热点,多项研究表明UPS的异常变化与炎症、糖尿病、肝肾疾病、肿瘤等疾病的发生有关,与神经系统疾病也有着密不可分的联系.本文就泛素-蛋白酶体系统的组成及其在神经系统疾病中的作用和治疗进展进行综述.
The ubiquitin-proteasome system(UPS)is an internal protein breakdown mechanism regulating a series of cellular life processes.It plays a critical role in protein turnover in most cells to remove old,damaged,and misfolded proteins,which is closely related to the development and progression of various diseases.In recent years,this system has been in the spotlight in various research fields.Studies have shown that abnormal changes in UPS are related to inflamma-tion,diabetes,liver and kidney diseases,and tumors,as well as nervous system diseases.This article reviews the compo-sition of UPS,its role in neurological diseases,and associated therapeutic progress.
唐瑞天;刘文虎;梁金;刘宗宝;陈合成
甘肃省人民医院脑血管病中心,甘肃省脑血管病重点实验室,甘肃 兰州 730000甘肃省人民医院神经外科二病区,甘肃兰州 730000
临床医学
泛素-蛋白酶体系统降解神经系统泛素
Ubiquitin-proteasome systemDegradationNervous systemUbiquitin
《中风与神经疾病杂志》 2024 (006)
567-571 / 5
甘肃省脑血管病临床研究中心(20JR10RA431);兰州市科技计划项目(2022-3-6);甘肃省人民医院院内科研基金项目(21GSSYB-14);甘肃省人民医院院内基金(17GSSY6-4)
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