医药导报2024，Vol.43Issue(7)：1084-1089,6.DOI:10.3870/j.issn.1004-0781.2024.07.011
外周脑源性细胞外囊泡作为神经精神疾病生物标志物和治疗监测标志物的前景与展望
Prospects of Peripheral Brain-derived Extracellular Vesicles as Biomarkers for Neuropsychiatric Disorders and Treatment Monitoring
摘要
Abstract
Extracellular vesicles(EV)are a group of membrane-bound structures that originate from the endosomal system or are shed from the plasma membrane of cells.EVs can carry a heterogeneous set of molecules,including proteins,lipids,nucleic acids,and membrane receptors from their cell of origin.EV can cross the blood-brain barrier,allowing brain-derived EV(BDEV)to be specifically extracted from peripheral blood using surface markers on neuronal cells.Due to the presence of signals from the central nervous system,such as proteins,lipids,and nucleic acids,BDEV has emerged as a promising tool for exploring the central nervous system.This article provided an overview of the feasibility of BDEV as biomarkers for neurological and psychiatric disorders,as well as their potential for monitoring therapeutic efficacy in the treatment process.关键词
细胞外囊泡/脑源性细胞外囊泡/中枢神经系统/神经精神疾病/生物标志物/药物疗效监测Key words
Extracellular vesicles/Brain-derived extracellular vesicles/Central nervous system/Neuropsychiatric disorder/Biomarker/Therapeutic drug monitoring分类
医药卫生引用本文复制引用
谢新晖,徐淑娴,刘忠纯..外周脑源性细胞外囊泡作为神经精神疾病生物标志物和治疗监测标志物的前景与展望[J].医药导报,2024,43(7):1084-1089,6.基金项目
国家自然科学基金资助项目(U21A20364). （U21A20364）
