医药导报2024，Vol.43Issue(7)：1107-1111,5.DOI:10.3870/j.issn.1004-0781.2024.07.015
计算机模拟在中药汤剂掩味研究中的应用
Application of Computer Simulation in the Taste-masking of Traditional Chinese Medicine Decoction
摘要
Abstract
The research on taste masking of traditional Chinese decoction is mostly focused on the use of taste or intelligent sensory equipment in macroscopic view,which makes it difficult to explain its internal mechanism microscopically.Computer simulation(CS)can describe the mechanism of material action from a microscopic or mesoscopic perspective and has been widely used in materials science and other fields.The decoction is a complex system composed of various types of bitter or non-bitter small molecules.Although it is difficult to apply CS directly,CS can still be used to study the taste masking mechanism based on the current decoction taste masking technology.In this paper,the general situation of taste masking of decoction and CS technology is briefly introduced.Based on the application of CS in other fields,the advantages and future application directions of CS in the research field of bitter mechanism and taste masking mechanism of traditional Chinese medicine decoction are discussed from the perspective of the interaction between the bitter molecule and taste masking molecule,bitter molecule,and bitter receptor,taste masking molecule and bitter receptor,bitter molecule/taste-masking compound and bitter receptor.It provides ideas for exploring new methods of taste masking of traditional Chinese medicine decoction and enriches the research of taste masking of traditional Chinese medicine.关键词
中药汤剂/计算机模拟/掩味机制/微观Key words
Traditional Chinese medicine decoction/Computer simulation/Taste-masking mechanism/Microscopic view分类
医药卫生引用本文复制引用
李晨旭,李学林,姚静,张璞,戴幸星,侯富国,施钧瀚,桂新景,张璐,刘瑞新..计算机模拟在中药汤剂掩味研究中的应用[J].医药导报,2024,43(7):1107-1111,5.基金项目
国家自然科学基金资助项目(81774452,81001646) （81774452,81001646）
河南省中医药拔尖人才培养项目资助(2019ZYBJ07) （2019ZYBJ07）
国家重点研发计划中医药现代化重点专项(2017YFC1703400) （2017YFC1703400）
河南省高层次人才特殊支持"中原千人计划"-"中原青年拔尖人才"项目(ZYQR201912158) （ZYQR201912158）
河南省卫生健康中青年学科带头人专项(HNSWJW-2020014) （HNSWJW-2020014）
国家中医药管理局2022年青年岐黄学者培养项目(国中医药人教函[2022]256号). （国中医药人教函[2022]256号）
