医药导报2024，Vol.43Issue(7)：1135-1138,4.DOI:10.3870/j.issn.1004-0781.2024.07.019
硫酸多黏菌素B在两种溶媒中的含量稳定性
Content Stability of Polymyxin B Sulfate in Two Solvents
摘要
Abstract
Objective To investigate the content stability of polymyxin B sulfate in high concentration solution and its finished infusion,and to provide a scientific basis for clinical administration.Methods Polymyxin B sulfate was dissolved in 0.9%sodium chloride injection and 5%glucose solution to the concentrations of 0.5 mg·mL-1,1 mg·mL-1 and 5 mg·mL-1,respectively.The content of polymyxin B was determined at 0,2,4,6,8,12,16,20 and 24 h by high-performance liquid chromatography under storage conditions of 4℃and 25℃.Results Polymyxin B sulfate was stable in the concentrations of 0.5 mg·mL-1,1 mg·mL-1 and 5 mg·mL-1,respectively,in 0.9%sodium chloride injection or 5%glucose injection.Under the storage conditions of 4℃and 25℃,the content of polymyxin B1 and polymyxin B2 ranged from 97.23%to 101.26%and 97.30%to 102.63%,respectively.Conclusion Polymyxin B sulfate was stable within 24 h dissolved either in 0.9%sodium chloride injection or in 5%glucose injection with the concentrations of 0.5 mg·mL-1,1 mg·mL-1 and 5 mg·mL-1 under the storage condition of 4℃and 25℃.关键词
硫酸多黏菌素B/高效液相色谱法/稳定性Key words
Polymyxin B sulfate/High performance liquid chromatography/Stability分类
医药卫生引用本文复制引用
石金芳,王玮,姚青青,王未,高杰..硫酸多黏菌素B在两种溶媒中的含量稳定性[J].医药导报,2024,43(7):1135-1138,4.基金项目
苏州市科技发展计划指导性项目(SKYXD2022020). （SKYXD2022020）
