罗汉果皂苷V对RSL3诱导的SH-SY5Y细胞铁死亡的抑制作用及其机制OA北大核心CSTPCD
Inhibitory effect of mogroside V on RSL3-induced ferroptosis of SH-SY5Y cells and its mechanism
目的:探讨罗汉果皂苷V(MV)对铁死亡诱导剂RAS选择性致死分子3(RSL3)诱导的人神经母细胞瘤SH-SY5Y细胞铁死亡的抑制作用及可能机制.方法:用RSL3诱导SH-SY5Y细胞建立铁死亡模型.MTT法检测细胞活力;倒置显微镜观察细胞形态;亚铁离子荧光探针FerroFarRed检测细胞内亚铁离子含量;线粒体红色荧光探针MitoTracker Red CMXRos检测线粒体膜电位(MMP);超氧化物阴离子荧光探针二氢乙啶和线粒体超氧化物红色荧光…查看全部>>
AIM:To investigate the inhibitory effect of mogroside V(MV)on ferroptosis of human neuroblas-toma SH-SY5Y cells induced by RAS-selective lethal 3(RSL3),and to explore its possible mechanism.METHODS:To establish a model of ferroptosis,the SH-SY5Y cell was induced by RSL3.The cell viability and cellular morphology were determined by MTT assay and inverted microscopy,respectively.The intracellular ferrous ion content was measured by ferrous ion fluorescence pro…查看全部>>
刘艳;夏荣松;冉冬芝;彭哲;王红
重庆医科大学,重庆 400016重庆医科大学,重庆 400016||重庆市人民医院药学部,重庆 401147重庆医科大学,重庆 400016重庆医科大学附属妇女儿童医院,重庆市妇幼保健院,重庆 401147重庆医科大学,重庆 400016
中医学
罗汉果皂苷V神经母细胞瘤RSL3化合物铁死亡SLC7A11/GPX4信号通路
mogroside VneuroblastomaferroptosisRSL3 compoundSLC7A11/GPX4 signaling pathway
《中国病理生理杂志》 2024 (6)
1033-1042,10
重庆市留学回国创业创新支持计划(No.X10419)
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